Evidence map›Paper›PMID 28475038›Full record

ArticleeLife2017

Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis.

Kerstin Seidel, Pauline Marangoni, Cynthia Tang, Bahar Houshmand, Wen Du, Richard L Maas, Steven Murray, Michael C Oldham, Ophir D Klein

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 57 citations in OpenAlex.

  1. Proceedings of the National Academy of Sciences of the United States of America · 2025
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  9. Craniofacial developmental biology in the single-cell era.Development (Cambridge, England) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kerstin SeidelDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, United States.
Pauline MarangoniDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, United States.ORCID http://orcid.org/0000-0002-4355-7322
Cynthia TangDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, United States.
Bahar HoushmandDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, United States.
Wen DuDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, United States.
Richard L MaasDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
Steven MurrayThe Jackson Laboratory, Bar Harbor, United States.
Michael C OldhamDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, United States.
Ophir D KleinDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, United States.ORCID http://orcid.org/0000-0002-6254-7082
University of California, San Francisco · USBrigham and Women's Hospital · USJackson Laboratory · US

Funding

Harnessing natural stem cell-based strategies for mammalian dental renewalR35DE026602 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEIN, OPHIR D · 2016 to 2023
$8.0M
CRE Driver Strain ResourcesR24OD011190 · OD · JACKSON LABORATORY · PI MURRAY, STEPHEN A, SMITH, CYNTHIA LOUISE · 2012 to 2022
$7.9M
Molecular Regulation of Early OdontogenesisR37DE011697 · NIDCR · BRIGHAM AND WOMEN'S HOSPITAL · PI MAAS, RICHARD L · 2002 to 2011
$3.6M
Rapid Identification and Validation of Human Craniofacial Development GenesU01DE024443 · NIDCR · BRIGHAM AND WOMEN'S HOSPITAL · PI MAAS, RICHARD L · 2014 to 2018
$2.9M
SysCODE Interdisciplinary postdoctoral Training Grant (8 of 10)RL9RL9EB008539 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 2007 to 2011
$1.2M
The role of Hippo and YAP/TAZ in dental renewalR01DE024988 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEIN, OPHIR D · 2015 to 2016
$793k
REGULATION OF STAGE SPECIFIC PROCESSES DURING STEM CELL BASED DENTAL RENEWALK99DE024214 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEIDEL, KERSTIN · 2014 to 2015
$202k
NIBIB NIH HHS RL9 EB008539NIDCR NIH HHS K99 DE024214NIDCR NIH HHS R01 DE024988NIDCR NIH HHS R35 DE026602NIDCR NIH HHS R37 DE011697NIDCR NIH HHS U01 DE024443NIH HHS R24 OD011190
6 · The paper itself

Abstract

Investigations into stem cell-fueled renewal of an organ benefit from an inventory of cell type-specific markers and a deep understanding of the cellular diversity within stem cell niches. Using the adult mouse incisor as a model for a continuously renewing organ, we performed an unbiased analysis of gene co-expression relationships to identify modules of co-expressed genes that represent differentiated cells, transit-amplifying cells, and residents of stem cell niches. Through in vivo lineage tracing, we demonstrated the power of this approach by showing that co-expression module members

Indexed as

Gene Expression ProfilingAnimalsBiomarkersCarrier ProteinsCell LineageIncisorMembrane GlycoproteinsMiceNerve Tissue ProteinsStem CellsBiomarkersCarrier ProteinsIGFBP5-interacting protein, mouseLrig1 protein, mouseMembrane GlycoproteinsNerve Tissue Proteinsco-expression analysisdevelopmental biologyincisorlineage tracingmousestem cellstem cells

Identifiers

PMID28475038
PMCPMC5419740
OpenAlexW2610640934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.