Evidence map›Paper›PMID 28474815›Full record

Trial reportImmunity, inflammation and disease2017

Probiotic supplementation promotes a reduction in T-cell activation, an increase in Th17 frequencies, and a recovery of intestinal epithelium integrity and mitochondrial morphology in ART-treated HIV-1-positive patients.

Gabriella d'Ettorre, Giacomo Rossi, Carolina Scagnolari, Mauro Andreotti, Noemi Giustini, Sara Serafino, Ivan Schietroma, Giuseppe Corano Scheri, Saeid Najafi Fard, Vito Trinchieri and 9 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Immunity, inflammation and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. The Hitchhiker Guide to CD4Frontiers in immunology · 2021
    Pooled it
  3. Trial
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  13. Review
  14. Association between CD4BMC infectious diseases · 2021
    Article
  15. Article
  16. Review
  17. Lights and Shadows of Microbiota Modulation and Cardiovascular Risk in HIV Patients.International journal of environmental research and public health · 2021
    Review
  18. Probing the Interface of HIV and Inflammaging.Current HIV/AIDS reports · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Gabriella d'EttorreDepartment of Public Health and Infectious Diseases, Azienda Policlinico Umberto I of Rome, Rome, Italy.
Giacomo RossiSchool of Biosciences, Veterinary Medicine University of Camerino, Matelica, Italy.
Carolina ScagnolariLaboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Mauro AndreottiDepartment of Therapeutic Research and Medicines Evaluation, Italian Institute of Health, Rome, Italy.
Noemi GiustiniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Sara SerafinoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Ivan SchietromaDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Giuseppe Corano ScheriDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Saeid Najafi FardDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Vito TrinchieriDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Paola MastromarinoSection of Microbiology, Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Carla SelvaggiLaboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Silvia ScarponaSchool of Biosciences, Veterinary Medicine University of Camerino, Matelica, Italy.
Gianfranco FanelloDepartment of Emergency Surgery-Emergency Endoscopic Unit, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Fausto FioccaDepartment of Emergency Surgery-Emergency Endoscopic Unit, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Giancarlo CeccarelliDepartment of Public Health and Infectious Diseases, Azienda Policlinico Umberto I of Rome, Rome, Italy.
Guido AntonelliLaboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Jason M BrenchleyLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Vincenzo VulloDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITIstituto Pasteur · ITPoliclinico Umberto I · ITUniversità di Camerino · ITNational Institute of Allergy and Infectious Diseases · USNational Institute of Health · AM

Funding

Mechanisms of Immune Activation and Disease Progression in Animal ModelsZIAAI001029 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BRENCHLEY, JASON · 2009 to 2025
$28.2M
6 · The paper itself

Abstract

introductionHIV infection is characterized by a persistent immune activation associated to a compromised gut barrier immunity and alterations in the profile of the fecal flora linked with the progression of inflammatory symptoms. The effects of high concentration multistrain probiotic (Vivomixx®, Viale del Policlinico 155, Rome, Italy in EU; Visbiome®, Dupont, Madison, Wisconsin in USA) on several aspects of intestinal immunity in ART-experienced HIV-1 patients was evaluated.

methodsA sub-study of a longitudinal pilot study was performed in HIV-1 patients who received the probiotic supplement twice a day for 6 months (T6). T-cell activation and CD4+ and CD8+ T-cell subsets expressing IFNγ (Th1, Tc1) or IL-17A (Th17, Tc17) were stained by cytoflorimetric analysis. Histological and immunohistochemical analyses were performed on intestinal biopsies while enterocytes apoptosis index was determined by TUNEL assay.

resultsA reduction in the frequencies of CD4

conclusionsThese findings highlight the potential beneficial effects of probiotic supplementation for the reconstitution of physical and immunological integrity of the mucosal intestinal barrier in ART-treated HIV-1-positive patients.

Indexed as

HIV SeropositivityAdultAnti-Retroviral AgentsCD8-Positive T-LymphocytesHIV-1HumansIntestinal MucosaLymphocyte ActivationMaleMiddle AgedMitochondriaProbioticsTh17 CellsTh1 CellsAnti-Retroviral AgentsapoptosisGALTGUTHIV-1HSP60IELsimmunityprobioticsTc1Tc17T-cell activationTh1Th17

Identifiers

PMID28474815
PMCPMC5569369
OpenAlexW2607084817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.