Evidence map›Paper›PMID 28474754›Full record

ArticleAngewandte Chemie (International ed. in English)2017

Ultrasensitive Measurement of Ca

Patrick Flagmeier, Suman De, David C Wirthensohn, Steven F Lee, Cécile Vincke, Serge Muyldermans, Tuomas P J Knowles, Sonia Gandhi, Christopher M Dobson, David Klenerman

Open access · bronzeAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 84 citations in OpenAlex.

  1. Article
  2. A Single-Molecule Liposome Assay for Membrane Permeabilization.Angewandte Chemie (International ed. in English) · 2025
    Article
  3. Molecular Determinants of Protein Pathogenicity at the Single-Aggregate Level.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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  15. Article
  16. Tween-20 Induces the Structural Remodeling of Single Lipid Vesicles.The journal of physical chemistry letters · 2022
    Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Patrick FlagmeierDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.ORCID 0000-0002-1204-5340
Suman DeDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.ORCID 0000-0003-1675-0773
David C WirthensohnDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.ORCID 0000-0003-4403-9436
Steven F LeeDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.ORCID 0000-0003-4492-5139
Cécile VinckeLaboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.ORCID 0000-0003-0681-7444
Serge MuyldermansLaboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.ORCID 0000-0002-3678-3575
Tuomas P J KnowlesDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.ORCID 0000-0002-7879-0140
Sonia GandhiDepartment of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.ORCID 0000-0003-4395-2661
Christopher M DobsonDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.ORCID 0000-0002-5445-680X
David KlenermanDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.ORCID 0000-0001-7116-6954
University of Cambridge · GBVrije Universiteit Brussel · BEQueen Mary University of London · GB

Funding

European Research Council 669237Wellcome Trust
6 · The paper itself

Abstract

To quantify and characterize the potentially toxic protein aggregates associated with neurodegenerative diseases, a high-throughput assay based on measuring the extent of aggregate-induced Ca

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesCalciumClusterinFluorescent DyesHumansKineticsLipid BilayersOptical ImagingProtein AggregatesProtein BindingSingle-Domain AntibodiesAmyloid beta-PeptidesCalciumClusterinFluorescent DyesLipid BilayersProtein AggregatesSingle-Domain AntibodiesAlzheimer's diseasefluorescence imagingnano-scale biophysicsneurodegenerationprotein aggregation

Identifiers

PMID28474754
PMCPMC5615231
OpenAlexW2611519591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.