Evidence map›Paper›PMID 28474580›Full record

ArticleBioMedicine2017

Etodolac and the risk of acute pancreatitis.

Kuan-Fu Liao, Kao-Chi Cheng, Cheng-Li Lin, Shih-Wei Lai

Abstract read
In one paragraph

Article in BioMedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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  6. Association between allopurinol use and hepatocellular carcinoma in a case-control study in Taiwan.European journal of hospital pharmacy : science and practice · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kuan-Fu LiaoCollege of Medicine, Tzu Chi University, Hualien 970, Taiwan - Department of Internal Medicine, Taichung Tzu Chi General Hospital, Taichung 427, Taiwan - Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan.
Kao-Chi ChengCollege of Medicine, China Medical University, Taichung 404, Taiwan - Department of Family Medicine, China Medical University Hospital, Taichung 404, Taiwan.
Cheng-Li LinCollege of Medicine, China Medical University, Taichung 404, Taiwan - Management Office for Health Data, China Medical University Hospital, Taichung 404, Taiwan.
Shih-Wei LaiCollege of Medicine, China Medical University, Taichung 404, Taiwan - Department of Family Medicine, China Medical University Hospital, Taichung 404, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to explore the association between etodolac use and acute in Taiwan.

designWe designed a case-control study using the database of Taiwan's National Health Insurance. SUBJECTS: In all, 7577 subjects aged 20 years or older with newly diagnosed acute pancreatitis were defined as cases, and 27032 sex-matched and age-matched subjects without acute pancreatitis were defined as controls. The period considered for this study was from 1998 to 2011. For the study, never having used etodolac is defined as a subject never receiving a prescription for etodolac. Active use of etodolac is defined as a subject receiving at least 1 prescription for etodolac within 7 days of the date of their being diagnosed with acute pancreatitis. Non-active use of etodolac is defined as a subject not receiving a prescription for etodolac within 7 days but receiving at least 1 prescription for etodolac ≥ 8 days before the date of their being diagnosed with acute pancreatitis.

main outcome measureThe association between etodolac use and acute pancreatitis was estimated by using the multivariable unconditional logistic regression model.

resultsAfter correcting for covariates, the adjusted odds ratio of acute pancreatitis was 3.78 for subjects with active use of etodolac (95% confidence interval 1.11, 12.9), compared with subjects who never used etodolac. The adjusted odds ratio decreased to 1.18 for subjects with non-active use of etodolac (95% confidence interval 0.38, 3.67), but that was without statistical significance.

conclusionThere could be an association between active use of etodolac and acute pancreatitis. Clinicians should take into account the possibility of etodolac-associated acute pancreatitis when patients currently using etodolac present with acute pancreatitis with an unknown cause.

Identifiers

PMID28474580
PMCPMC5439338

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