Evidence map›Paper›PMID 28474579›Full record

ArticleBioMedicine2017

Effects of swimming exercise on nerve regeneration in a rat sciatic nerve transection model.

Chien-Fu Liao, Tse-Yen Yang, Yung-Hsiang Chen, Chun-Hsu Yao, Tzong-Der Way, Yueh-Sheng Chen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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  11. Molecular mechanisms of exercise contributing to tissue regeneration.Signal transduction and targeted therapy · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Chien-Fu LiaoDepartment of Biological Science and Technology, China Medical University, Taichung 404, Taiwan.
Tse-Yen YangDepartment of Medical Research, China Medical University Hospital, Taichung 404, Taiwan.
Yung-Hsiang ChenGraduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan - Department of Psychology, Asia University, Wufeng District, Taichung 413, Taiwan.
Chun-Hsu YaoBiomaterials Translational Research Center, China Medical University Hospital, Taichung 404, Taiwan - Department of Biomedical Informatics, Asia University, Wufeng District, Taichung 413, Taiwan.
Tzong-Der WayDepartment of Biological Science and Technology, China Medical University, Taichung 404, Taiwan.
Yueh-Sheng ChenBiomaterials Translational Research Center, China Medical University Hospital, Taichung 404, Taiwan - Department of Biomedical Informatics, Asia University, Wufeng District, Taichung 413, Taiwan - Lab of Biomaterials, School of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
China Medical University · TWChina Medical University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSwimming is commonly considered to be an efficient rehabilitation exercise to treat peripheral nerve injury. However, the most effective resistance level and exercise duration is still unclear. We investigated the effects and mechanisms of swimming at various exertion levels in a rat sciatic nerve transection model.

methodsSciatic nerve transection rats were randomized into the following four groups based on swimming duration (from the 7th day to the 28th day post-surgery): sedentary control group (SC), S10 group (10 min/3 times/week), S20 group (20 min/3 times/week), and S30 group (30 min/3 times/week) (n = 10 each). Axon regeneration, electrophysiological properties, muscular weights, macrophage infiltration, and nerve repair associated maker, calcitonin gene-related peptide (CGRP), were measured.

resultsDramatic higher successful percentages of nerve regeneration across the 10-mm gaps in swimming groups compared to the SC group. Total area of nerve regeneration significantly improved in the S10 group; however, electrophysiological properties, muscular weights, and macrophage infiltration in the regenerated nerves of rats did not differ significantly between the various exercise groups. CGRP expression was significantly increased in the spinal cord of rats in the S20 group.

conclusionsOur data indicated that CGRP-related axonal regeneration improved significantly with moderate swimming. These results should inspire new studies in physiotherapeutic practice for related human treatment.

Identifiers

PMID28474579
PMCPMC5439339
OpenAlexW2591748681

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.