Evidence map›Paper›PMID 28474484›Full record

ArticleAging cell2017

Hyaluronan keeps mesenchymal stem cells quiescent and maintains the differentiation potential over time.

Tzyy Yue Wong, Chiung-Hsin Chang, Chen-Hsiang Yu, Lynn L H Huang

Open access · goldAbstract read
In one paragraph

Article in Aging cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 43 citations in OpenAlex.

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  12. Toxicological research · 2021
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  19. Expansion of mesenchymal stem cells on electrospun scaffolds maintains stemness, mechano-responsivity, and differentiation potential.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tzyy Yue WongInstitute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Chiung-Hsin ChangDepartment of Obstetrics and Gynecology, National Cheng Kung University, Tainan, Taiwan.
Chen-Hsiang YuDepartment of Obstetrics and Gynecology, National Cheng Kung University, Tainan, Taiwan.
Lynn L H HuangInstitute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
National Cheng Kung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyaluronan (HA), an abundant polysaccharide found in human bodies, plays a role in the mesenchymal stem cells (MSCs) maintenance. We had previously found that HA prolonged the lifespan, and prevented the cellular aging of murine adipose-derived stromal cells. Recently, we had also summarized the potential pathways associated with HA regulation in human MSCs. In this study, we used the human placenta-derived MSCs (PDMSC) to investigate the effectiveness of HA in maintaining the PDMSC. We found that coating the culture surface coated with 30 μg cm

Indexed as

AdipocytesCell DifferentiationCell MovementChondrocytesCytoskeletal ProteinsFemaleGene Expression RegulationHumansHyaluronic AcidMesenchymal Stem CellsOsteoblastsPlacentaPregnancyPrimary Cell CultureResting Phase, Cell CycleTelomeraseCytoskeletal ProteinsHyaluronic AcidTelomeraseTERT protein, humananti-aginghyaluronanlifespanmesenchymal stem cellsquiescence

Identifiers

PMID28474484
PMCPMC5418204
OpenAlexW2610160914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.