Evidence map›Paper›PMID 28474409›Full record

ArticleMagnetic resonance in medicine2018

Amide proton transfer CEST of the cervical spinal cord in multiple sclerosis patients at 3T.

Samantha By, Robert L Barry, Alex K Smith, Bailey D Lyttle, Bailey A Box, Francesca R Bagnato, Siddharama Pawate, Seth A Smith

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. ISMRM Clinical Focus Meeting 2023: "Imaging the Fire in the Brain".Journal of magnetic resonance imaging : JMRI · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. TowardBiosensors · 2022
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Samantha ByDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Robert L BarryAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Alex K SmithDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0001-8005-9982
Bailey D LyttleVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Bailey A BoxVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Francesca R BagnatoDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Siddharama PawateDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Seth A SmithDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Vanderbilt University Medical Center · USVanderbilt University · USHarvard University · US

Funding

Microstructural Characterization of the Optic Nerve in Optic NeuritisR01EY023240 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SMITH, SETH A · 2014 to 2017
$1.0M
Functional Imaging and resting state connectivity in human spinal cord at 7 TeslaR00EB016689 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BARRY, ROBERT L · 2016 to 2018
$747k
In Vivo Macromolecular and Protein-Based MRI in the Spinal Cord of MS PatientsR21NS087465 · NINDS · VANDERBILT UNIVERSITY · PI SMITH, SETH A · 2014 to 2015
$431k
Functional Imaging and Resting State Connectivity in Human Spinal Cord at 7 TeslaK99EB016689 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BARRY, ROBERT L · 2014 to 2015
$178k
NEI NIH HHS R01 EY023240NIBIB NIH HHS K99 EB016689NIBIB NIH HHS R00 EB016689NINDS NIH HHS R21 NS087465
6 · The paper itself

Abstract

purposeThe ability to evaluate pathological changes in the spinal cord in multiple sclerosis (MS) is limited because T

methodsAPT CEST of the cervical spinal cord was obtained in a cohort of 10 controls and 10 MS patients using a novel respiratory correction methodology. APT was quantified using two methods: 1) APT

resultsRespiratory correction yielded highly reproducible z-spectra in white matter (intraclass correlation coefficient = 0.82). APT

conclusionRespiration correction in the spinal cord is necessary to accurately quantify APT CEST, which can provide unique biochemical information regarding disease processes within the spinal cord. Magn Reson Med 79:806-814, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Indexed as

AdultAmidesCase-Control StudiesCervical CordFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisProtonsWhite MatterYoung AdultAmidesProtonsamide proton transferCESTmultiple sclerosisnormal-appearing white matterspinal cord

Identifiers

PMID28474409
PMCPMC5777527
OpenAlexW2611885390

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.