ArticleHuman brain mapping2017
Tackling variability: A multicenter study to provide a gold-standard network approach for frontotemporal dementia.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries.Frontiers in neurology · 2021Pooled it
- Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research.Frontiers in neurology · 2021Pooled it
- Towards affordable biomarkers of frontotemporal dementia: A classification study via network's information sharing.Scientific reports · 2017Trial
- A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Brain Topology Disruption in Early-Onset Dementia: Review of Current Findings and the Need for Network Resilience Focused Models.Brain and behavior · 2025Review
- Multiplex connectomics reveal altered networks in frontotemporal dementia: A multisite study.Network neuroscience (Cambridge, Mass.) · 2025Article
- Neuroanatomical markers of social cognition in neglected adolescents.Neurobiology of stress · 2024Article
- The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds.Scientific data · 2023Article
- Social and non-social working memory in neurodegeneration.Neurobiology of disease · 2023Article
- Visual deep learning of unprocessed neuroimaging characterises dementia subtypes and generalises across non-stereotypic samples.EBioMedicine · 2023Article
- Clinical relevance of disrupted topological organization of anatomical connectivity in behavioral variant frontotemporal dementia.Neurobiology of aging · 2023Article
- Article
- Temporal Irreversibility of Large-Scale Brain Dynamics in Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Moral Emotions and Their Brain Structural Correlates Across Neurodegenerative Disorders.Journal of Alzheimer's disease : JAD · 2023Article
- The impact of regional heterogeneity in whole-brain dynamics in the presence of oscillations.Network neuroscience (Cambridge, Mass.) · 2023Article
- Multiclass characterization of frontotemporal dementia variants via multimodal brain network computational inference.Network neuroscience (Cambridge, Mass.) · 2023Article
- Multidimensional inhibitory signatures of sentential negation in behavioral variant frontotemporal dementia.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Functional connectivity in behavioral variant frontotemporal dementia.Brain and behavior · 2022Review
- Multimodal Neurocognitive Markers of Naturalistic Discourse Typify Diverse Neurodegenerative Diseases.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases.Brain : a journal of neurology · 2022Article
Corrections and comments
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomarkers represent a critical research area in neurodegeneration disease as they can contribute to studying potential disease-modifying agents, fostering timely therapeutic interventions, and alleviating associated financial costs. Functional connectivity (FC) analysis represents a promising approach to identify early biomarkers in specific diseases. Yet, virtually no study has tested whether potential FC biomarkers prove to be reliable and reproducible across different centers. As such, their implementation remains uncertain due to multiple sources of variability across studies: the numerous international centers capable conducting FC research vary in their scanning equipment and their samples' socio-cultural background, and, more troublingly still, no gold-standard method exists to analyze FC. In this unprecedented study, we aim to address both issues by performing the first multicenter FC research in the behavioral-variant frontotemporal dementia (bvFTD), and by assessing multiple FC approaches to propose a gold-standard method for analysis. We enrolled 52 bvFTD patients and 60 controls from three international clinics (with different fMRI recording parameters), and three additional neurological patient groups. To evaluate FC, we focused on seed analysis, inter-regional connectivity, and several graph-theory approaches. Only graph-theory analysis, based on weighted-matrices, yielded consistent differences between bvFTD and controls across centers. Also, graph metrics robustly discriminated bvFTD from the other neurological conditions. The consistency of our findings across heterogeneous contexts highlights graph-theory as a potential gold-standard approach for brain network analysis in bvFTD. Hum Brain Mapp 38:3804-3822, 2017. © 2017 Wiley Periodicals, Inc.
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