ArticleAllergy2017
Airway basophils are increased and activated in eosinophilic asthma.
Article in Allergy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Activation of lung megakaryocyte α7 nAChR exacerbates allergic airway inflammation via IL-33/p38 MAPK signaling.JCI insight · 2026Article
- The PGDCommunications biology · 2026Article
- Diagnostic Use of CCR3, CD63, CD203c and FcεRIα on Blood Leukocytes of Allergic Asthma and Combined Allergic Rhinitis and Asthma Syndrome.Journal of cellular and molecular medicine · 2025Article
- Thymic stromal lymphopoietin as a therapeutic target in patients with chronic rhinosinusitis and nasal polyps.Clinical and experimental immunology · 2025Review
- Increased sputum peripheral helper T cells are associated with the severity of rheumatoid arthritis but not with the severity of airway disease.Frontiers in immunology · 2025Article
- Identification of Novel Biomarkers Associated with Corticosteroid Resistance in Asthma by Bioinformatics Analysis and Experimental Validation.Journal of inflammation research · 2025Article
- Blood eosinophil count correlates with alveolar damage in emphysema-predominant COPD.BMC pulmonary medicine · 2024Article
- Effects of increasing sensitizing doses of ovalbumin on airway hyperresponsiveness in asthmatic mice.Immunity, inflammation and disease · 2024Article
- The Functional Role of Group 2 Innate Lymphoid Cells in Asthma.Biomolecules · 2023Review
- Involvement of Transforming Growth Factor-β-Associated Kinase 1 in Fixed Airway Obstruction in Asthmatic Patients with Longer Disease Duration Independent on Airway Eosinophilia.Journal of asthma and allergy · 2023Article
- Forthcoming complications in recovered COVID-19 patients with COPD and asthma; possible therapeutic opportunities.Cell communication and signaling : CCS · 2022Review
- The role of human mast cells in allergy and asthma.Bioengineered · 2022Review
- Diagnostic Accuracy of Liquid Biomarkers in Airway Diseases: Toward Point-of-Care Applications.Frontiers in medicine · 2022Review
- Role of Basophils in a Broad Spectrum of Disorders.Frontiers in immunology · 2022Review
- Basophils from allergy to cancer.Frontiers in immunology · 2022Review
- CD25 as a unique marker on human basophils in stable-mildly symptomatic allergic asthma.Frontiers in immunology · 2022Article
- Risk Factors Predicting Severe Asthma Exacerbations in Adult Asthmatics: A Real-World Clinical Evidence.Allergy, asthma & immunology research · 2021Article
- Group 2 Innate Lymphoid Cells: Team Players in Regulating Asthma.Annual review of immunology · 2021Article
- Clinical Differences between Early- and Late-Onset Asthma: A Population-Based Cross-Sectional Study.Canadian respiratory journal · 2021Article
- Role of myeloid cells in the regulation of group 2 innate lymphoid cell-mediated allergic inflammation.Immunology · 2020Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe impact of basophils on asthma pathogenesis remains largely unexplored, particularly in humans. Here, we evaluated the frequencies and activation status of basophils in the sputum of adult asthmatic patients and related our findings to other parameters of eosinophilic airway inflammation.
methodsWe enrolled 44 adult asthmatic patients who were being treated with inhaled corticosteroids (ICS). Analysis of the induced sputum, exhaled nitric oxide fraction (FeNO) measurement, and asthma control test (ACT) were carried out together with standard blood and pulmonary function tests. The cellular composition of the sputum was examined by flow cytometry, and the phenotypes of blood and sputum basophils were compared.
resultsBasophils were increased in the sputum of asthmatic patients. The expression of CD203c on sputum basophils was significantly higher than that on blood basophils. The percentage of sputum basophils was positively correlated with those of eosinophils and mast cells; it was also correlated with that of blood eosinophils and FeNO. However, sputum basophils were not correlated with serum IgE, lung function, or the percentage of blood basophils. A receiver-operating characteristic (ROC) curve showed the superiority of sputum basophils as a surrogate marker of the percentages of sputum eosinophils compared with absolute numbers of blood eosinophils and FeNO.
conclusionThe number of activated basophils was increased in the sputum of patients with eosinophilic asthma and correlated with airway and blood eosinophils. Our observations suggest that sputum basophils may serve as a biomarker to monitor new therapeutic approaches for the treatment of eosinophilic asthma.
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