Evidence map›Paper›PMID 28474304›Full record

ArticleJournal of cardiovascular translational research2017

The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy.

Hilde M Norum, Kaspar Broch, Annika E Michelsen, Ida G Lunde, Tove Lekva, Aurelija Abraityte, Christen P Dahl, Arnt E Fiane, Arne K Andreassen, Geir Christensen and 4 more

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Article in Journal of cardiovascular translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Observational
  5. Review
  6. Article
  7. A perspective on Notch signalling in progression and arrhythmogenesis in familial hypertrophic and dilated cardiomyopathies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  8. Observational
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Host-DerivedFrontiers in cellular and infection microbiology · 2019
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Hilde M NorumResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway. hnorum@rr-research.no.
Kaspar BrochDepartment of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Annika E MichelsenResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Ida G LundeCenter for Heart Failure Research, University of Oslo, Oslo, Norway.
Tove LekvaResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Aurelija AbraityteResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Christen P DahlResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Arnt E FianeDepartment of Cardiothoracic Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Arne K AndreassenDepartment of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Geir ChristensenCenter for Heart Failure Research, University of Oslo, Oslo, Norway.
Svend AakhusDepartment of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Pål AukrustResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Lars GullestadFaculty of Medicine, University of Oslo, Oslo, Norway.
Thor UelandResearch Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Oslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In dilated cardiomyopathy (DCM), adverse myocardial remodeling is essential, potentially involving Notch signaling. We hypothesized that secreted Notch ligands would be dysregulated in DCM. We measured plasma levels of the canonical Delta-like Notch ligand 1 (DLL1) and non-canonical Notch ligands Delta-like 1 homologue (DLK1) and periostin (POSN) in 102 DCM patients and 32 matched controls. Myocardial mRNA and protein levels of DLL1, DLK1, and POSN were measured in 25 explanted hearts. Our main findings were: (i) Circulating levels of DLL1 and POSN were higher in patients with severe DCM and correlated with the degree of diastolic dysfunction and (ii) right ventricular tissue expressions of DLL1, DLK1, and POSN were oppositely associated with cardiac function indices, as high DLL1 and DLK1 expression corresponded to more preserved and high POSN expression to more deteriorated cardiac function. DLL1, DLK1, and POSN are dysregulated in end-stage DCM, possibly mediating different effects on cardiac function.

Indexed as

Ventricular Function, LeftAdultAgedBiomarkersCalcium-Binding ProteinsCardiomyopathy, DilatedCase-Control StudiesCell Adhesion MoleculesDiastoleFemaleHumansIntercellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiddle AgedSeverity of Illness IndexBiomarkersCalcium-Binding ProteinsCell Adhesion MoleculesDLK1 protein, humanIntercellular Signaling Peptides and ProteinsMembrane ProteinsPOSTN protein, humanDelta-like 1 homologue (DLK1)Delta-like Notch ligand 1 (DLL1)Diastolic dysfunctionDilated cardiomyopathyMyocardial remodelingNotch pathwayPeriostin (POSN)

Identifiers

PMID28474304
OpenAlexW2611319069

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.