Evidence map›Paper›PMID 28474229›Full record

Trial reportJournal of autism and developmental disorders2017

Dose-Response Effects of Long-Acting Liquid Methylphenidate in Children with Attention Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD): A Pilot Study.

Soo-Jeong Kim, Sophia Shonka, William P French, Jennifer Strickland, Lindsey Miller, Mark A Stein

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of autism and developmental disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

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  13. Frontiers in molecular neuroscience · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Soo-Jeong KimUniversity of Washington, Seattle, WA, USA.
Sophia ShonkaSeattle Children's Research Institute, Seattle, WA, USA.
William P FrenchUniversity of Washington, Seattle, WA, USA.
Jennifer StricklandSeattle Children's Research Institute, Seattle, WA, USA.
Lindsey MillerSeattle Children's Research Institute, Seattle, WA, USA.
Mark A SteinUniversity of Washington, Seattle, WA, USA. Mark.stein@seattlechildrens.org.
University of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Attention deficit/hyperactivity disorder (ADHD) symptoms are common in youth with autism spectrum disorders (ASD) and are frequently treated with stimulant medications. Twenty-seven children were randomized to different dose titration schedules, and ADHD symptoms, tolerability, and aberrant behaviors were assessed weekly during a 6-week trial with long-acting liquid methylphenidate (MPH). MPH at low to moderate doses was effective in reducing ADHD symptoms and was well tolerated in young children with ASD and ADHD. Future studies are needed to assess generalization and maintenance of efficacy.

Indexed as

AdolescentAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderCentral Nervous System StimulantsChildDose-Response Relationship, DrugFemaleHumansMaleMethylphenidatePilot ProjectsCentral Nervous System StimulantsMethylphenidateADHDASDAttention deficit hyperactivity disorderAutism spectrum disorderMethylphenidate

Identifiers

PMID28474229
OpenAlexW2611352611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.