ArticleBrain structure & function2017
Do all roads lead to Rome? A comparison of brain networks derived from inter-subject volumetric and metabolic covariance and moment-to-moment hemodynamic correlations in old individuals.
Article in Brain structure & function, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Human cerebral cortex organization characterized by functional PET-FDG "Metabolic Connectivity".European journal of nuclear medicine and molecular imaging · 2026Article
- Effects of Tasks on Functional Brain Connectivity Derived from Interindividual Correlations: Insights from Regional Homogeneity of Functional MRI Data.Brain connectivity · 2025Article
- Effects of Tasks on Functional Brain Connectivity Derived from Inter-Individual Correlations: Insights from Regional Homogeneity of Functional MRI Data.bioRxiv : the preprint server for biology · 2025Article
- FDG-PET-based brain network analysis: a brief review of metabolic connectivity.EJNMMI reports · 2025Review
- Stable brain PET metabolic networks using a multiple sampling scheme.Network neuroscience (Cambridge, Mass.) · 2025Article
- Cognitive flexibility's role in shaping self-perception of aging, body appreciation, and self-efficacy among community-dwelling older women.BMC nursing · 2024Article
- Similarity between structural and proxy estimates of brain connectivity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Associations of white matter hyperintensities with networks of gray matter blood flow and volume in midlife adults: A coronary artery risk development in young adults magnetic resonance imaging substudy.Human brain mapping · 2022Article
- Tau deposition patterns are associated with functional connectivity in primary tauopathies.Nature communications · 2022Article
- Article
- Multimodal Imaging Analysis Reveals Frontal-Associated Networks in Relation to Individual Resilience Strength.International journal of environmental research and public health · 2021Article
- Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease.Nature communications · 2020Article
- Structural Covariance Reveals Alterations in Control and Salience Network Integrity in Chronic Schizophrenia.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Interregional causal influences of brain metabolic activity reveal the spread of aging effects during normal aging.Human brain mapping · 2019Article
- Functional resting-state brain connectivity is accompanied by dynamic correlations of application-dependent [NeuroImage · 2019Article
- Multimodal neuroimaging analysis reveals age-associated common and discrete cognitive control constructs.Human brain mapping · 2019Article
- Toward Task Connectomics: Examining Whole-Brain Task Modulated Connectivity in Different Task Domains.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Functional connectivity associated with tau levels in ageing, Alzheimer's, and small vessel disease.Brain : a journal of neurology · 2019Article
- Impact of sex and reproductive status on memory circuitry structure and function in early midlife using structural covariance analysis.Human brain mapping · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Relationships between spatially remote brain regions in human have typically been estimated by moment-to-moment correlations of blood-oxygen-level dependent signals in resting-state using functional MRI (fMRI). Recently, studies using subject-to-subject covariance of anatomical volumes, cortical thickness, and metabolic activity are becoming increasingly popular. However, question remains on whether these measures reflect the same inter-region connectivity and brain network organizations. In the current study, we systematically analyzed inter-subject volumetric covariance from anatomical MRI images, metabolic covariance from fluorodeoxyglucose positron emission tomography images from 193 healthy subjects, and resting-state moment-to-moment correlations from fMRI images of a subset of 44 subjects. The correlation matrices calculated from the three methods were found to be minimally correlated, with higher correlation in the range of 0.31, as well as limited proportion of overlapping connections. The volumetric network showed the highest global efficiency and lowest mean clustering coefficient, leaning toward random-like network, while the metabolic and resting-state networks conveyed properties more resembling small-world networks. Community structures of the volumetric and metabolic networks did not reflect known functional organizations, which could be observed in resting-state network. The current results suggested that inter-subject volumetric and metabolic covariance do not necessarily reflect the inter-regional relationships and network organizations as resting-state correlations, thus calling for cautions on interpreting results of inter-subject covariance networks.
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Registered trials
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