ReviewFrontiers in public health2017
Salivary Diagnostics in Pediatrics: Applicability, Translatability, and Limitations.
Review in Frontiers in public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Infant hyperglycemic excursions by saliva 1,5-anhydroglucitol varied by weight status, rapid weight gain, and mode of feeding: an exploratory secondary analysis.The American journal of clinical nutrition · 2026Trial
- Rapid maxillary expansion related sutural and dentoalveolar changes provoke early-term oxidative stress.BMC oral health · 2026Trial
- Biomarkers for Necrotising Enterocolitis-Are We There Yet?Children (Basel, Switzerland) · 2026Review
- Non-invasive epigenetic protein signatures associated with childhood obesity.Clinical epigenetics · 2026Article
- The Double Burden: Understanding the Impact of Malnutrition on Childhood Cancer Outcomes in Resource-Limited Settings.International journal of pediatrics · 2026Review
- Salivary C-Reactive Protein: A Non-Invasive Alternative to Serum CRP in Pediatric Acute Appendicitis.Molecules (Basel, Switzerland) · 2025Article
- Salivary Proteome Insights: Evaluation of Saliva Preparation Methods in Mucopolysaccharidoses Research.Biomedicines · 2025Article
- Measuring Children's Stress via Saliva in Surgical and Endoscopic Procedures and Its Measurement Intention in the Community: Reality-Future Prospects.Children (Basel, Switzerland) · 2023Article
- Diagnostic Accuracy of Leucine-Rich α-2-Glycoprotein 1 as a Non-Invasive Salivary Biomarker in Pediatric Appendicitis.International journal of molecular sciences · 2023Article
- Case report: marfan syndrome (MFS) mimicking cutaneous vasculitis.Frontiers in pediatrics · 2023Article
- Association Between Salivary Cytokines, Chemokines and Growth Factors and Salivary Gland Function in Children with Chronic Kidney Disease.Journal of inflammation research · 2023Article
- A rapid and non-invasive proteomic analysis using DBS and buccal swab for multiplexed second-tier screening of Pompe disease and Mucopolysaccharidosis type I.Molecular genetics and metabolism · 2022Article
- A comparison of epithelial cell content of oral samples estimated using cytology and DNA methylation.Epigenetics · 2022Article
- Recent Major Transcriptomics and Epitranscriptomics Contributions toward Personalized and Precision Medicine.Journal of personalized medicine · 2022Review
- Host-Based Biomarkers in Saliva for the Diagnosis of Pulmonary Tuberculosis in Children: A Mini-Review.Frontiers in pediatrics · 2021Review
- Dynamics of salivary markers of kidney functions in acute and chronic kidney diseases.Scientific reports · 2020Article
- Minimally Invasive Biospecimen Collection for Exposome Research in Children's Health.Current environmental health reports · 2020Review
- Salivary biomarker for acute appendicitis in children: a pilot study.Pediatric surgery international · 2020Article
- Unstimulated Parotid Saliva Sampling in Juvenile Idiopathic Arthritis and Healthy Controls: A Proof-of-Concept Study on Biomarkers.Diagnostics (Basel, Switzerland) · 2020Article
- Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last decade, technological advances, combined with an improved appreciation of the ability of saliva to inform caregivers about both oral health and systemic disease, have led to the emergence of salivary diagnostic platforms. However, the majority of these assays have targeted diseases that more commonly affect the adult population, largely neglecting infants and children who arguably could benefit the most from non-invasive assessment tools for health monitoring. Gaining access into development, infection, and disease through comprehensive "omic" analyses of saliva could significantly improve care and enhance health access. In this review, we will highlight novel applications of salivary diagnostics in pediatrics across the "omic" spectrum, including at the genomic, transcriptomic, proteomic, microbiomic, and metabolomic level. The challenges to implementing salivary platforms into care, including the effects of age, diet, and developmental stage on salivary components, will be reviewed. Ultimately, large-scale, multicenter trials must be performed to establish normative biomarker values across the age spectrum to accurately discriminate between health and disease. Only then can salivary diagnostics truly translate into pediatric care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.