ArticleVeterinary research forum : an international quarterly journal2017
Changes in the expression of OCT4 in mouse ovary during estrous cycle.
Article in Veterinary research forum : an international quarterly journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Revitalizing polycystic ovary syndrome: The therapeutic impact of low-dose ∆ tetrahydrocannabinol-9 through reduction of oxidative stress and modulation of macrophage polarization.Iranian journal of basic medical sciences · 2024Article
- An Experimental Study on The Oxidative Status and Inflammatory Levels of A Rat Model of Polycystic Ovary Syndrome Induced by Letrozole and A New High-Fat Diet.International journal of fertility & sterility · 2023Article
- The Effect of Melatonin on OCT4 Expression and Granulosa Cell Growth in Female Mice.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Effects of omega-3 polyunsaturated fatty acids on cellular development in human ovarian granulosa tumor cells (KGN).Frontiers in nutrition · 2022Article
- Evaluation of stemness marker expression in bovine ovarian granulosa cells.Animal reproduction · 2019Article
- Role of OCT4 in the Regulation of FSH-Induced Granulosa Cells Growth in Female Mice.Frontiers in endocrinology · 2019Article
- Polysaccharides ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Evaluation of changes in the expression of Wnt/β-catenin target genes in mouse reproductive tissues during estrous cycle: An experimental study.International journal of reproductive biomedicine · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcriptional factor OCT4 regulates pluripotency of stem cells and has an important role during oocyte growth. Whereas, its role has remained ambiguous in ovarian tissue during reproductive cycle. Therefore, this study was aimed to investigate the expression patterns of OCT4 in mouse ovaries during the normal estrous cycle. Adult National Medical Research Institute mice were classified as proestrous, estrous, metestrous and diestrous on the basis of vaginal smear cytology. Their ovaries were removed and the protein and gene expression levels of OCT4 were assessed using immunohistochemical staining and real-time quantitative reverse-transcription PCR, respectively. Immunohistochemical staining revealed the expression of OCT4 in the cytoplasm of corpus luteum cells. In the follicles, OCT4 was expressed in the cytoplasm of granulosa cells. Furthermore, the gene expression levels of OCT4 was significantly higher in the proestrous phase than in the other phases of the estrous cycle (
Indexed as
Identifiers
28473896PMC5413310W2611906055What OpenQuestion holds
Registered trials
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