ArticleFrontiers in biology2017
The radial organization of neuronal primary cilia is acutely disrupted by seizure and ischemic brain injury.
Article in Frontiers in biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Cilia in the brain display region-dependent oscillations of length and orientation.PLoS biology · 2025Article
- Ultrastructural differences impact cilia shape and external exposure across cell classes in the visual cortex.Current biology : CB · 2024Article
- Mapping of neuronal and glial primary cilia contactome and connectome in the human cerebral cortex.Neuron · 2024Article
- Nanometer-scale views of visual cortex reveal anatomical features of primary cilia poised to detect synaptic spillover.bioRxiv : the preprint server for biology · 2023Article
- Seizure enhances SUMOylation and zinc-finger transcriptional repression in neuronal nuclei.iScience · 2023Article
- A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility.Cell · 2022Article
- Primary cilia in the postnatal brain: Subcellular compartments for organizing neuromodulatory signaling.Current opinion in neurobiology · 2022Review
- Diverged morphology changes of astrocytic and neuronal primary cilia under reactive insults.Molecular brain · 2020Article
- Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.Scientific reports · 2019Article
- [Pulsed electromagnetic fields stimulating osteogenic differentiation and maturation involves primary cilia-PI3K/AKT pathway].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2019Article
- Primary cilia as a novel horizon between neuron and environment.Neural regeneration research · 2017Review
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
backgroundNeuronal primary cilia are sensory organelles that are critically involved in the proper growth, development, and function of the central nervous system (CNS). Recent work also suggests that they signal in the context of CNS injury, and that abnormal ciliary signaling may be implicated in neurological diseases.
methodsWe quantified the distribution of neuronal primary cilia alignment throughout the normal adult mouse brain by immunohistochemical staining for the primary cilia marker adenylyl cyclase III (ACIII) and measuring the angles of primary cilia with respect to global and local coordinate planes. We then introduced two different models of acute brain insult-temporal lobe seizure and cerebral ischemia, and re-examined neuronal primary cilia distribution, as well as ciliary lengths and the proportion of neurons harboring cilia.
resultsUnder basal conditions, cortical cilia align themselves radially with respect to the cortical surface, while cilia in the dentate gyrus align themselves radially with respect to the granule cell layer. Cilia of neurons in the striatum and thalamus, by contrast, exhibit a wide distribution of ciliary arrangements. In both cases of acute brain insult, primary cilia alignment was significantly disrupted in a region-specific manner, with areas affected by the insult preferentially disrupted. Further, the two models promoted differential effects on ciliary lengths, while only the ischemia model decreased the proportion of ciliated cells.
conclusionsThese findings provide evidence for the regional anatomical organization of neuronal primary cilia in the adult brain and suggest that various brain insults may disrupt this organization.
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