ArticleFrontiers in biology2016
Transgenic mouse models for studying adult neurogenesis.
Article in Frontiers in biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Hilar mossy cell oxytocin receptor signaling regulates adult hippocampal neurogenesis and context discrimination in mice.Journal of biomedical science · 2026Article
- The KAP1 chromatin regulator and Paupar long non-coding RNA control subventricular zone neural stem cell maintenance and neurogenesis.Stem cell reports · 2025Article
- Computationally resolved neuroprogenitor cell biomarkers associate with human disorders.Stem cell reports · 2025Article
- Neurogenesis in primates versus rodents and the value of non-human primate models.National science review · 2023Review
- The Influence of Sex on Hippocampal Neurogenesis and Neurotrophic Responses on the Persistent Effects of Adolescent Intermittent Ethanol Exposure into Adulthood.Neuroscience · 2022Article
- Estimation of the density of neural, glial, and endothelial lineage cells in the adult mouse dentate gyrus.Neural regeneration research · 2022Article
- Epigenetic regulation in the neurogenic niche of the adult dentate gyrus.Neuroscience letters · 2022Review
- Prenatal overexpression of platelet-derived growth factor receptor A results in central nervous system hypomyelination.Brain and behavior · 2021Article
- Glial PAMPering and DAMPening of Adult Hippocampal Neurogenesis.Brain sciences · 2021Review
- BASP1 labels neural stem cells in the neurogenic niches of mammalian brain.Scientific reports · 2021Article
- Steps towards standardized quantification of adult neurogenesis.Nature communications · 2020Review
- Transgenic models for investigating the nervous system: Currently available neurofluorescent reporters and potential neuronal markers.Biochimica et biophysica acta. General subjects · 2020Review
- VCAM1 Labels a Subpopulation of Neural Stem Cells in the Adult Hippocampus and Contributes to Spatial Memory.Stem cell reports · 2020Article
- Understanding the Real State of Human Adult Hippocampal Neurogenesis From Studies of Rodents and Non-human Primates.Frontiers in neuroscience · 2020Review
- Imaging Mass Spectrometry: A New Tool to Assess Molecular Underpinnings of Neurodegeneration.Metabolites · 2019Review
- A PCR-Based Method for RNA Probes and Applications in Neuroscience.Frontiers in neuroscience · 2018Article
- Multitype Bellman-Harris branching model provides biological predictors of early stages of adult hippocampal neurogenesis.BMC systems biology · 2017Article
- Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance.eLife · 2017Article
- A question of fate.PLoS biology · 2017Article
- Pattern Separation: A Potential Marker of Impaired Hippocampal Adult Neurogenesis in Major Depressive Disorder.Frontiers in neuroscience · 2017Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
The mammalian hippocampus shows a remarkable capacity for continued neurogenesis throughout life. Newborn neurons, generated by the radial neural stem cells (NSCs), are important for learning and memory as well as mood control. During aging, the number and responses of NSCs to neurogenic stimuli diminish, leading to decreased neurogenesis and age-associated cognitive decline and psychiatric disorders. Thus, adult hippocampal neurogenesis has garnered significant interest because targeting it could be a novel potential therapeutic strategy for these disorders. However, if we are to use neurogenesis to halt or reverse hippocampal-related pathology, we need to understand better the core molecular machinery that governs NSC and their progeny. In this review, we summarize a wide variety of mouse models used in adult neurogenesis field, present their advantages and disadvantages based on specificity and efficiency of labeling of different cell types, and review their contribution to our understanding of the biology and the heterogeneity of different cell types found in adult neurogenic niches.
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