Evidence map›Paper›PMID 28473750›Full record

ArticleFrontiers in neuroscience2017

No Association between Cortical Gyrification or Intrinsic Curvature and Attention-deficit/Hyperactivity Disorder in Adolescents and Young Adults.

Natalie J Forde, Lisa Ronan, Marcel P Zwiers, Aaron F Alexander-Bloch, Stephen V Faraone, Jaap Oosterlaan, Dirk J Heslenfeld, Catharina A Hartman, Jan K Buitelaar, Pieter J Hoekstra

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Cortical Thickness and Curvature in Autism and ADHD: A Mega-Analysis.bioRxiv : the preprint server for biology · 2026
    Article
  4. Neural correlates of inattention in adults with ADHD.European archives of psychiatry and clinical neuroscience · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Cognitive slowing and its underlying neurobiology in temporal lobe epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2019
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Natalie J FordeDepartment of Psychiatry, University of Groningen, University Medical Center GroningenGroningen, Netherlands.
Lisa RonanBrain Mapping Unit, Department of Psychiatry, University of CambridgeCambridge, UK.
Marcel P ZwiersDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical CenterNijmegen, Netherlands.
Aaron F Alexander-BlochBrain Mapping Unit, Department of Psychiatry, University of CambridgeCambridge, UK.
Stephen V FaraoneDepartments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical UniversitySyracuse, NY, USA.
Jaap OosterlaanClinical Neuropsychology Section, Department of Clinical, Neuro and Developmental Psychology, Vrije Universiteit AmsterdamAmsterdam, Netherlands.
Dirk J HeslenfeldClinical Neuropsychology Section, Department of Clinical, Neuro and Developmental Psychology, Vrije Universiteit AmsterdamAmsterdam, Netherlands.
Catharina A HartmanDepartment of Psychiatry, University of Groningen, University Medical Center GroningenGroningen, Netherlands.
Jan K BuitelaarDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical CenterNijmegen, Netherlands.
Pieter J HoekstraDepartment of Psychiatry, University of Groningen, University Medical Center GroningenGroningen, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic resonance imaging (MRI) studies have highlighted subcortical, cortical, and structural connectivity abnormalities associated with attention-deficit/hyperactivity disorder (ADHD). Gyrification investigations of the cortex have been inconsistent and largely negative, potentially due to a lack of sensitivity of the previously used morphological parameters. The innovative approach of applying intrinsic curvature analysis, which is predictive of gyrification pattern, to the cortical surface applied herein allowed us greater sensitivity to determine whether the structural connectivity abnormalities thus far identified at a centimeter scale also occur at a millimeter scale within the cortical surface. This could help identify neurodevelopmental processes that contribute to ADHD. Structural MRI datasets from the NeuroIMAGE project were used [

Indexed as

ADHDbiomarkerconnectivitydevelopmentgyrificationintrinsic curvature

Identifiers

PMID28473750
PMCPMC5397412

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.