ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Activity Clamp Provides Insights into Paradoxical Effects of the Anti-Seizure Drug Carbamazepine.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Actions of the antiseizure drug carbamazepine in the thalamic reticular nucleus: Potential mechanism of aggravating absence seizures.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- BICS01 Mediates Reversible Anti-seizure Effects in Brain Slice Models of Epilepsy.Frontiers in neurology · 2021Article
- Neuronal-Specific Inhibition of Endoplasmic Reticulum MgBrain sciences · 2020Article
- In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy.Brain : a journal of neurology · 2020Article
- dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2020Article
- Ictal Inhibition: Sync Globally, Slack Locally.Epilepsy currentsArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
A major challenge in experimental epilepsy research is to reconcile the effects of anti-epileptic drugs (AEDs) on individual neurons with their network-level actions. Highlighting this difficulty, it is unclear why carbamazepine (CBZ), a frontline AED with a known molecular mechanism, has been reported to increase epileptiform activity in several clinical and experimental studies. We confirmed in an
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.