ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Anterolateral Entorhinal Cortex Volume Predicted by Altered Intra-Item Configural Processing.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 65 citations in OpenAlex.
- Decoding memory function through naturalistic gaze patterns.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Object fine-grained discrimination as a sensitive cognitive marker of transentorhinal integrity.Communications biology · 2025Article
- A mouse model of early sporadic tau pathology induces neurogenic plasticity in the hippocampus.PloS one · 2025Article
- The Effect of Segmentation Method on Medial Temporal Lobe Subregion Volumes in Aging.Human brain mapping · 2024Article
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- Sex and menstrual cycle influence human spatial navigation strategies and performance.Scientific reports · 2023Article
- Targeting the function of the transentorhinal cortex to identify early cognitive markers of Alzheimer's disease.Cognitive, affective & behavioral neuroscience · 2023Review
- Elucidating medial temporal and frontal lobe contributions to approach-avoidance conflict decision-making using functional MRI and the hierarchical drift diffusion model.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Differential Laminar Activation Dissociates Encoding and Retrieval in the Human Medial and Lateral Entorhinal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Single voxel autocorrelation uncovers gradients of temporal dynamics in the hippocampus and entorhinal cortex during rest and navigation.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Tau PET burden in Brodmann areas 35 and 36 is associated with individual differences in cognition in non-demented older adults.Frontiers in aging neuroscience · 2023Article
- Assessing mild cognitive impairment using object-location memory in immersive virtual environments.Hippocampus · 2022Article
- Article
- Network activity changes in the pathophysiology of Alzheimer's disease: the role of aging and early entorhinal cortex dysfunction.Metabolic brain disease · 2022Review
- Effect of aging differs for memory of object identity and object position within a spatial context.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Perirhinal Cortex is Involved in the Resolution of Learned Approach-Avoidance Conflict Associated with Discrete Objects.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Anterolateral entorhinal cortex volume is associated with memory retention in clinically unimpaired older adults.Neurobiology of aging · 2021Article
- Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.PloS one · 2021Article
- The intersection between the oculomotor and hippocampal memory systems: empirical developments and clinical implications.Annals of the New York Academy of Sciences · 2020Review
- Anterolateral entorhinal cortex thickness as a new biomarker for early detection of Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent functional imaging studies have proposed that the human entorhinal cortex (ERC) is subdivided into functionally distinct anterolateral (alERC) and posteromedial (pmERC) subregions. The alERC overlaps with regions that are affected earliest by Alzheimer's disease pathology, yet its cognitive function remains poorly understood. Previous human fMRI studies have focused on its role in object memory, but rodent studies on the putatively homologous lateral entorhinal cortex suggest that it also plays an important role in representing spatial properties of objects. To investigate the cognitive effects of human alERC volume differences, we developed an eye-tracking-based task to evaluate intra-item configural processing (i.e., processing the arrangement of an object's features) and used manual segmentation based on a recently developed protocol to delineate the alERC/pmERC and other medial temporal lobe (MTL) subregions. In a group of older adult men and women at varying stages of brain atrophy and cognitive decline, we found that intra-item configural processing, regardless of an object's novelty, was strongly predicted by alERC volume, but not by the volume of any other MTL subregion. These results provide the first evidence that the human alERC plays a role in supporting a distinct aspect of object processing, namely attending to the arrangement of an object's component features.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.