Evidence map›Paper›PMID 28473593›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2017

Molecular Imaging of PARP.

Brandon Carney, Susanne Kossatz, Thomas Reiner

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Translational Potential of Fluorescent PARP1 Inhibitor as a Molecular Contrast Agent for Diagnosis of Basal Cell Carcinoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Advances in PET imaging of cancer.Nature reviews. Cancer · 2023
    Review
  10. Review
  11. Review
  12. Article
  13. Fully Automated, High-Dose Radiosynthesis of [Pharmaceuticals (Basel, Switzerland) · 2022
    Article
  14. Review
  15. Multiplexed imaging in oncology.Nature biomedical engineering · 2022
    Review
  16. Two experts and a newbie: [European journal of nuclear medicine and molecular imaging · 2022
    Article
  17. Review
  18. A phase I study of a PARP1-targeted topical fluorophore for the detection of oral cancer.European journal of nuclear medicine and molecular imaging · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Brandon CarneyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Susanne KossatzDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Thomas ReinerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York reinert@mskcc.org.
Cornell University · USHunter College · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Radioiodinated Multifunctional PARP1 Imaging Probes for Diagnosis and TherapyR01CA204441 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PILLARSETTY, NAGAVARAKISHORE · 2016 to 2020
$2.9M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204441
6 · The paper itself

Abstract

The poly(adenosine diphosphate-ribose)polymerase (PARP) family of enzymes is an important factor in the cellular DNA damage response and has gained much attention for its role in many diseases, particularly cancer. Targeted molecular imaging of PARP using fluorescent or radiolabeled tags has followed on the success of therapeutic inhibitors and gained momentum over the past few years. This review covers PARP imaging from the very first imaging agents up to the current state of the technology, with a focus on the clinical applications made possible by these agents.

Indexed as

AnimalsHumansImage EnhancementIsotope LabelingMolecular ImagingNeoplasmsPoly(ADP-ribose) PolymerasesPositron-Emission TomographyRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificityPoly(ADP-ribose) PolymerasesRadiopharmaceuticalsfluorescenceopticalPARPPETSPECTtranslation

Identifiers

PMID28473593
PMCPMC5493005
OpenAlexW2611270172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.