ArticleCancer research2017
Oncogenic RAS Regulates Long Noncoding RNA
Open access · bronzeAbstract read
In one paragraph
Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Tumor-associated macrophage-derived exosomes LINC01592 induce the immune escape of esophageal cancer by decreasing MHC-I surface expression.Journal of experimental & clinical cancer research : CR · 2023Article
- Shining a light on the dark proteome: Non-canonical open reading frames and their encoded miniproteins as a new frontier in cancer biology.Protein science : a publication of the Protein Society · 2023Review
- GBAP1 functions as a tumor promotor in hepatocellular carcinoma via the PI3K/AKT pathway.BMC cancer · 2023Article
- KRAS-related long noncoding RNAs in human cancers.Cancer gene therapy · 2022Review
- Emerging role of non-coding RNAs in the regulation of KRAS.Cancer cell international · 2022Review
- The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma.Molecular oncology · 2022Review
- The role of lncRNAs in the tumor microenvironment and immunotherapy of melanoma.Frontiers in immunology · 2022Review
- LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathway.Molecular therapy. Nucleic acids · 2021Article
- Construction of a Ferroptosis-Related Long Non-coding RNA Prognostic Signature and Competing Endogenous RNA Network in Lung Adenocarcinoma.Frontiers in cell and developmental biology · 2021Article
- Identification and characterization of functional long noncoding RNAs in cancer.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Review
- LncRNAs in Cancer: From garbage to Junk.Cancers · 2020Review
- Non-Coding RNAs in Lung Tumor Initiation and Progression.International journal of molecular sciences · 2020Review
- The role of long non-coding RNA GAS5 in cancers.Cancer management and research · 2019Article
- Shedding Light on the Dark Cancer Genomes: Long Noncoding RNAs as Novel Biomarkers and Potential Therapeutic Targets for Cancer.Molecular cancer therapeutics · 2018Review
- The role of long noncoding RNAs in cancer: the dark matter matters.Current opinion in genetics & development · 2018Review
- Transcription Factor NFAT5 Promotes Glioblastoma Cell-driven Angiogenesis via SBF2-AS1/miR-338-3p-Mediated EGFL7 Expression Change.Frontiers in molecular neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 1 institution in 1 country.
Dongmei ZhangDepartment of Gynecology and Obstetrics, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Gao ZhangMelanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania.
Xiaowen HuCenter for Research on Reproduction & Women's Health, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Lawrence WuMelanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania.
Yi FengCenter for Research on Reproduction & Women's Health, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Sidan HeDepartment of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Youyou ZhangCenter for Research on Reproduction & Women's Health, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Zhongyi HuCenter for Research on Reproduction & Women's Health, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Lu YangDepartment of Gynecology and Obstetrics, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Tian TianDepartment of Computer Science, New Jersey Institute of Technology, Newark, New Jersey.
Weiting XuDepartment of Computer Science, New Jersey Institute of Technology, Newark, New Jersey.
Zhi WeiDepartment of Computer Science, New Jersey Institute of Technology, Newark, New Jersey.
Yiling LuDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Keith T FlahertyMassachusetts General Hospital Cancer Center, Boston, Massachusetts.
Xiaomin ZhongCenter for Research on Reproduction & Women's Health, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Gordon B MillsDepartment of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Phyllis A GimottyDepartment of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Xiaowei XuDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Meenhard HerlynMelanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania. linzhang@mail.med.upenn.edu herlynm@wistar.org.
Lin ZhangCenter for Research on Reproduction & Women's Health, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. linzhang@mail.med.upenn.edu herlynm@wistar.org.
Massachusetts General Hospital · US
Funding
UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 1985 to 2026
$222.3MTumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9MTargeting the MAP and PI3 Kinase Pathways in MelanomaP01CA114046 · NCI · WISTAR INSTITUTE · PI MURPHY, MAUREEN E. · 2008 to 2023
$37.1MTherapeutic Micro RNA Strategies for Ovarian CancerP50CA083638 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI GODWIN, ANDREW K., GOLEMIS, ERICA A. · 1999 to 2013
$33.6MTargeted Combination Therapy for MelanomaP50CA174523 · NCI · WISTAR INSTITUTE · PI HERLYN, MEENHARD F · 2014 to 2018
$11.1MOutreachU54HG008100 · NHGRI · OREGON HEALTH & SCIENCE UNIVERSITY · PI GRAY, JOE W., HEISER, LAURA MADELINE · 2014 to 2019
$10.5MThe epigenetic mechanism of long non-coding RNA in cancerR01CA190415 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ZHANG, LIN · 2015 to 2019
$1.8MThe role of microRNA, mir-30d, in the initiation and progression of cancerR01CA142776 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ZHANG, LIN · 2010 to 2014
$1.6MNCI NIH HHS P01 CA114046NCI NIH HHS P30 CA010815NCI NIH HHS P30 CA016520NCI NIH HHS P50 CA083638NCI NIH HHS P50 CA174523NCI NIH HHS R01 CA142776NCI NIH HHS R01 CA190415NHGRI NIH HHS U54 HG008100
Abstract
RAS and its downstream cascades transmit cellular signals, resulting in increased transcription of genes involved in cell growth and division. Protein-coding gene targets of RAS signaling have been characterized extensively, but long noncoding RNAs (lncRNA) regulated by these processes have not. Using a custom-designed lncRNA microarray, we identified the lncRNA
Indexed as
Genes, rasAnimalsCell Line, TumorCell ProliferationFemaleHeterograftsHigh-Throughput Nucleotide SequencingHumansMiceMice, NudeNeoplasmsRNA, Long NoncodingSignal TransductionRNA, Long Noncoding
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.