ArticleBMJ open2017
Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio associated with disease activity in patients with Takayasu's arteritis: a case-control study.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 76 citations in OpenAlex.
- Altered MicroRNA Signatures in Circulating Extracellular Vesicles Reflect Aortic Dilation in Takayasu Arteritis.Journal of extracellular biology · 2026Article
- Inflammatory blood count ratios discriminate disease activity and remain persistently elevated during glucocorticoid-free remission in ANCA-associated vasculitis.Clinical and experimental medicine · 2026Article
- Inflammatory parameters in idiopathic intracranial hypertension and their relationship with optic disc findings.International ophthalmology · 2026Article
- The Role of Neutrophil to Lymphocytes Ratio (NLR) as a Predictor of Disease Activity in Behcet's Syndrome-A Comprehensive Review.Journal of clinical medicine · 2025Review
- Correlation and Risk Assessment of Inflammation-Based Parameters on Cardiovascular Parameters and Clinical Events in Giant Cell Arteritis: A Retrospective Study.International journal of molecular sciences · 2025Article
- Combining biomarkers to predict the disease activity of graves' ophthalmopathy: a combinatory model of the NLR, TRAb and FT4.Frontiers in endocrinology · 2025Article
- Blood indices of inflammation and their association with hypertension in smokers: analysis using data mining approaches.Journal of human hypertension · 2025Article
- SIRI and SII as potential biomarkers of disease activity and lupus nephritis in systemic lupus erythematosus.Frontiers in immunology · 2025Article
- NLR (neutrophil to lymphocyte ratio), PLR (platelet to lymphocyte ratio), and SII (systemic immune-inflammation index) reflect disease activity and renal remission in patients with lupus nephritis.Frontiers in immunology · 2025Article
- Effector CD4+ T-cell subsets in Takayasu arteritis-differences between the peripheral blood and the aorta.Clinical and experimental immunology · 2024Article
- The significance of biomarkers of inflammation in predicting the activity of Lupus nephritis.Journal of medical biochemistry · 2024Article
- Are monocyte-to-HDL and C-reactive protein-to-albumin ratios useful for the diagnosis and follow-up of Takayasu arteritis?Revista da Associacao Medica Brasileira (1992) · 2024Article
- Application Value of Platelet-to-Lymphocyte Ratio as a Novel Indicator in Rheumatoid Arthritis: A Review Based on Clinical Evidence.Journal of inflammation research · 2024Review
- [Neutrophil-lymphocyte and platelet-lymphocyte ratios for assessing disease activity in patients with rheumatoid arthritis receiving tofacitinib treatment].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Importance of hematological markers in familial Mediterranean fever in terms of disease severity and amyloidosis.Rheumatology international · 2023Article
- The Role of Systemic Inflammation in Acquired Nasolacrimal Duct Obstruction.Beyoglu eye journal · 2023Article
- Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential markers for ulcerative colitis: a retrospective study.BMC gastroenterology · 2022Article
- Outcome Measures and Biomarkers for Disease Assessment in Takayasu Arteritis.Diagnostics (Basel, Switzerland) · 2022Review
- Systemic immune-inflammation index could be associated with pseudophakic cystoid macular edema after an uneventful phacoemulsification surgery in patients without risk factors.BMC ophthalmology · 2022Article
- The Predictive Role of Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), Monocytes-to-Lymphocyte Ratio (MLR) and Gammaglobulins for the Development of Cutaneous Vasculitis Lesions in Primary Sjögren's Syndrome.Journal of clinical medicine · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlatelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have been reported to reflect the inflammatory response and disease activity in a variety of autoimmune diseases.
objectivesThis study aimed to evaluate the value of PLR and NLR as markers to monitor disease activity in Takayasu's arteritis (TAK).
methodsA retrospective case-control study involving 88 patients with TAK and 78 healthy controls was performed. We compared the PLR and NLR between patients and healthy controls, and also analysed the correlations between PLR or NLR and indices of TAK disease activity.
resultsIncreased PLR and NLR were observed in patients with TAK. PLR was positively correlated with hs-C-reactive protein (hs-CRP) (r=0.239, p=0.010) and erythrocyte sedimentation rate (ESR) (r=0.270, p=0.010). NLR also exhibited a positive relationship with Kerr's score (r=0.284, p=0.002), hs-CRP (r=0.313, p=0.006) and ESR (r=0.249, p=0.019). A PLR level of 183.39 was shown to be the predictive cut-off value for TAK (sensitivity 37.8%, specificity 93.0%, area under the curve (AUC)=0.691). A NLR level of 2.417 was found to be the predictive cut-off value for TAK (sensitivity 75.6%, specificity 55.8%, AUC=0.697).
conclusionsPLR and NLR could be useful markers to reflect inflammation and disease activity in patients with TAK.
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