Evidence map›Paper›PMID 28473467›Full record

ArticleThe Journal of biological chemistry2017

Hepatic protein phosphatase 1 regulatory subunit 3B (Ppp1r3b) promotes hepatic glycogen synthesis and thereby regulates fasting energy homeostasis.

Minal B Mehta, Swapnil V Shewale, Raymond N Sequeira, John S Millar, Nicholas J Hand, Daniel J Rader

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 79 citations in OpenAlex.

  1. DietaryGenes · 2026
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  10. Science advances · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Minal B MehtaFrom the Division of Translational Medicine and Human Genetics.
Swapnil V ShewaleFrom the Division of Translational Medicine and Human Genetics.
Raymond N SequeiraFrom the Division of Translational Medicine and Human Genetics.
John S MillarFrom the Division of Translational Medicine and Human Genetics.
Nicholas J Handthe Department of Genetics, and.ORCID 0000-0002-8172-1816
Daniel J RaderFrom the Division of Translational Medicine and Human Genetics, rader@mail.med.upenn.edu.ORCID 0000-0002-9245-9876
Center for Human Genetics · USPediatrics and Genetics · US

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1986 to 2026
$48.3M
Molecular mechanisms and pathways of novel genomic loci regulating plasma lipidsRC2HL101864 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI RADER, DANIEL JAMES · 2009 to 2010
$4.7M
Genetics of Elevated High Density Lipoprotein CholesterolR01HL089309 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI RADER, DANIEL JAMES · 2008 to 2012
$3.9M
NHLBI NIH HHS R01 HL089309NHLBI NIH HHS RC2 HL101864NIDDK NIH HHS P30 DK019525
6 · The paper itself

Abstract

Maintenance of whole-body glucose homeostasis is critical to glycemic function. Genetic variants mapping to chromosome 8p23.1 in genome-wide association studies have been linked to glycemic traits in humans. The gene of known function closest to the mapped region,

Indexed as

AnimalsBlood GlucoseEnergy MetabolismFastingGene Expression Regulation, EnzymologicGluconeogenesisGlucose-6-PhosphataseGlycogenLiverMiceMice, KnockoutOrgan SpecificityPhosphoenolpyruvate Carboxykinase (ATP)Protein Phosphatase 1Blood GlucoseGlucose-6-PhosphataseGlycogenPhosphoenolpyruvate Carboxykinase (ATP)Ppp1r3b protein, mouseProtein Phosphatase 1Alb-Cregluconeogenesisglycogenglycogen storage diseaseglycogen synthaseglycolysisliverPpp1r3b

Identifiers

PMID28473467
PMCPMC5481556
OpenAlexW2610824927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.