Evidence map›Paper›PMID 28473436›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2017

DBA/2J Haplotype on Distal Chromosome 2 Reduces Mertk Expression, Restricts Efferocytosis, and Increases Susceptibility to Atherosclerosis.

Yukako Kayashima, Natalia Makhanova, Nobuyo Maeda

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Reduction ofFrontiers in cardiovascular medicine · 2022
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Functional Genomics and CRISPR Applied to Cardiovascular Research and Medicine.Arteriosclerosis, thrombosis, and vascular biology · 2019
    Article
  9. Updates on Approaches for Studying Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2019
    Article
  10. Reporting Sex and Sex Differences in Preclinical Studies.Arteriosclerosis, thrombosis, and vascular biology · 2018
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yukako KayashimaFrom the Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill.
Natalia MakhanovaFrom the Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill.
Nobuyo MaedaFrom the Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill. nobuyo@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
APOLIPOROTEIN GENES AND ATHEROGENESISR01HL042630 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAEDA, NOBUYO · 1989 to 2017
$4.9M
APOLIPOPROTEIN GENES AND ATHEROGENESIS IN ANIMALSR37HL042630 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAEDA, NOBUYO · 1998 to 2007
$3.4M
NCI NIH HHS P30 CA016086NHLBI NIH HHS R01 HL042630NHLBI NIH HHS R37 HL042630
6 · The paper itself

Abstract

objectiveAPPROACH AND

resultsTo dissect the strain effects of

conclusionsReduced transcription of

Indexed as

Chromosomes, MammalianHaplotypesPhagocytosisPlaque, AtheroscleroticAnimalsAorta, ThoracicAortic DiseasesApolipoproteins EApoptosisAtherosclerosisc-Mer Tyrosine KinaseDisease Models, AnimalDown-RegulationGene Expression Regulation, EnzymologicGenetic Predisposition to DiseaseHEK293 CellsApolipoproteins Ec-Mer Tyrosine KinaseMAS1 protein, humanMertk protein, mouseProto-Oncogene MasProto-Oncogene ProteinsReceptor Protein-Tyrosine Kinasesaortaatherosclerosismacrophagesmicephagocytosis

Identifiers

PMID28473436
PMCPMC5497749
OpenAlexW2611899409

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.