Evidence map›Paper›PMID 28473404›Full record

ArticleJournal of the American Heart Association2017

Graded Association Between Kidney Function and Impaired Orthostatic Blood Pressure Stabilization in Older Adults.

Mark Canney, Matthew D L O'Connell, Donal J Sexton, Neil O'Leary, Rose Anne Kenny, Mark A Little, Conall M O'Seaghdha

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Cognitive Impairment in End Stage Renal Disease Patients Undergoing Hemodialysis: Markers and Risk Factors.International journal of environmental research and public health · 2022
    Pooled it
  2. Observational
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  11. Observational
  12. Orthostatic blood pressure reduction as a possible explanation for memory deficits in dialysis patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Mark CanneyThe Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Dublin 2, Ireland mcanney@tcd.ie.
Matthew D L O'ConnellThe Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Dublin 2, Ireland.
Donal J SextonThe Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Dublin 2, Ireland.
Neil O'LearyThe Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Dublin 2, Ireland.
Rose Anne KennyThe Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Dublin 2, Ireland.
Mark A LittleTrinity Health Kidney Centre, Tallaght Hospital, Dublin 24, Ireland.
Conall M O'SeaghdhaDepartment of Renal Medicine, Beaumont Hospital, Dublin 9, Ireland.
Trinity College Dublin · IEBotsford Hospital · USTallaght University Hospital · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImpaired orthostatic blood pressure (BP) stabilization is highly prevalent in older adults and is a predictor of end-organ injury, falls, and mortality. We sought to characterize the relationship between postural BP responses and the kidney. METHODS AND

resultsWe performed a cross-sectional analysis of 4204 participants from The Irish Longitudinal Study on Ageing, a national cohort of community-dwelling adults aged ≥50 years. Beat-to-beat systolic and diastolic BP were measured during a 2-minute active stand test. The primary predictor was cystatin C estimated glomerular filtration rate (eGFR) categorized as follows (mL/min per 1.73 m

conclusionsWe report a novel, graded relationship between diminished eGFR and impaired orthostatic BP stabilization. Mapping the postural BP response merits further study in kidney disease as a potential means of identifying those at risk of hypotension-related events.

Indexed as

Blood PressureGlomerular Filtration RatePostureAgedAge FactorsBiomarkersChi-Square DistributionCystatin CFemaleHumansHypotension, OrthostaticIrelandKidneyLinear ModelsLogistic ModelsMaleBiomarkersCST3 protein, humanCystatin Cblood pressure measurement/monitoringcystatin Cglomerular filtration ratehypotensionkidneylow blood pressureorthostatic hypotension

Identifiers

PMID28473404
PMCPMC5524105
OpenAlexW2611238550

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.