Evidence map›Paper›PMID 28473328›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2017

TNFα decreases mitochondrial movement in human airway smooth muscle.

Philippe Delmotte, Vanessa A Zavaletta, Michael A Thompson, Y S Prakash, Gary C Sieck

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Molecular mechanisms underlying FCCP-induced mitophagy in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  3. AhR activation inhibits DRP1-induced mitochondrial fission in airway smooth muscle during asthma.American journal of respiratory cell and molecular biology · 2026
    Article
  4. Article
  5. Review
  6. TNFα-mediated subcellular heterogeneity of succinate dehydrogenase activity in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  7. Multifaceted roles of mitochondria in asthma.Cell biology and toxicology · 2024
    Review
  8. Article
  9. Article
  10. Molecular mechanisms underlying TNFα-induced mitochondrial fragmentation in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  11. Understanding the impact of ER stress on lung physiology.Frontiers in cell and developmental biology · 2024
    Review
  12. Nicotine affects mitochondrial structure and function in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Size-dependent differences in mitochondrial volume density in phrenic motor neurons.Journal of applied physiology (Bethesda, Md. : 1985) · 2023
    Article
  17. Mitochondrial adaptations to inactivity in diaphragm muscle fibers.Journal of applied physiology (Bethesda, Md. : 1985) · 2022
    Article
  18. Metabolomics in asthma: A platform for discovery.Molecular aspects of medicine · 2022
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Philippe DelmotteDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Vanessa A ZavalettaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Michael A ThompsonDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Y S PrakashDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-2968-224X
Gary C SieckDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota sieck.gary@mayo.edu.
Mayo Clinic · US

Funding

Neurotrophins in the LungR01HL088029 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S. · 2009 to 2022
$5.9M
Role of Mitochondria in Airway Smooth MuscleR01HL126451 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S., SIECK, GARY C. · 2015 to 2018
$1.9M
NHLBI NIH HHS R01 HL088029NHLBI NIH HHS R01 HL126451
6 · The paper itself

Abstract

In airway smooth muscle (ASM) cells, excitation-contraction coupling is accomplished via a cascade of events that connect an elevation of cytosolic Ca

Indexed as

Carrier ProteinsCytosolHistamineHumansIntracellular Signaling Peptides and ProteinsLungMicrotubulesMitochondriaMitochondrial ProteinsMuscle, SmoothMyocytes, Smooth MuscleNerve Tissue ProteinsNocodazolerho GTP-Binding ProteinsSarcoplasmic ReticulumTumor Necrosis Factor-alphaCarrier ProteinsHistamineIntracellular Signaling Peptides and ProteinsMitochondrial ProteinsNerve Tissue ProteinsNocodazolerho GTP-Binding ProteinsRHOT2 protein, humanTNF protein, humanTRAK2 protein, humanTumor Necrosis Factor-alphaairwayasthmaMiltonMiromitochondriaTNFα

Identifiers

PMID28473328
PMCPMC5538870
OpenAlexW2611018289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.