Evidence map›Paper›PMID 28473321›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2017

Hyperpolarized gas diffusion MRI of biphasic lung inflation in short- and long-term emphysema models.

Yi Xin, Maurizio Cereda, Stephen Kadlecek, Kiarash Emami, Hooman Hamedani, Ian Duncan, Jennia Rajaei, Liam Hughes, Natalie Meeder, Joseph Naji and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Yi XinDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Maurizio CeredaDepartment of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania.
Stephen KadlecekDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Kiarash EmamiPolarean, Incorpoarated, Durham, North Carolina.
Hooman HamedaniDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Ian DuncanDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Jennia RajaeiStanford University, Stanford, California; and.
Liam HughesDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Natalie MeederDepartment of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania.
Joseph NajiDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Harrilla ProfkaDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Brian J BologneseGlaxosmithkline, Incorpoarted, King of Prussia, Pennsylvania.
Joseph P FoleyGlaxosmithkline, Incorpoarted, King of Prussia, Pennsylvania.
Patricia L PodolinGlaxosmithkline, Incorpoarted, King of Prussia, Pennsylvania.
Rahim R RiziDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania; rizi@uphs.upenn.edu.
University of Pennsylvania · USGlaxoSmithKline (United States) · USStanford University · US

Funding

Prediction and assessment of COPD lung volume reduction outcomes with polarized MRIR01HL129805 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI RIZI, RAHIM R · 2016 to 2019
$3.0M
A New Approach for the Assessment of Pulmonary InflammationR01HL124986 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI RIZI, RAHIM R · 2015 to 2018
$3.0M
NHLBI NIH HHS R01 HL124986NHLBI NIH HHS R01 HL129805
6 · The paper itself

Abstract

During lung inflation, airspace dimensions are affected nonlinearly by both alveolar expansion and recruitment, potentially confounding the identification of emphysematous lung by hyperpolarized helium-3 diffusion magnetic resonance imaging (HP MRI). This study aimed to characterize lung inflation over a broad range of inflation volume and pressure values in two different models of emphysema, as well as in normal lungs. Elastase-treated rats (

Indexed as

AnimalsDiffusion Magnetic Resonance ImagingDisease Models, AnimalHeliumLungMiceMice, Inbred C57BLPancreatic ElastasePressurePulmonary EmphysemaRatsRats, Sprague-DawleySmokeHeliumPancreatic ElastaseSmokeapparent diffusion coefficienthyperpolarized gas magnetic resonance imaginglung dynamicslung physiology

Identifiers

PMID28473321
PMCPMC5582938
OpenAlexW2610749682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.