Evidence map›Paper›PMID 28473300›Full record

ArticleDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver2017

Allelic frequencies of the hs1.2 enhancer within the immunoglobulin heavy chain region in Dayton, Ohio patients screened for celiac disease with duodenal biopsy.

Jing Liu, Rebecca A Law, Paul G Koles, Jonathan C Saxe, Michael Bottomley, Courtney E W Sulentic

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PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jing LiuDepartment of Pharmacology & Toxicology, Wright State University, Dayton, OH, United States.
Rebecca A LawDepartment of Pharmacology & Toxicology, Wright State University, Dayton, OH, United States.
Paul G KolesDepartment of Pathology, Wright State University, Dayton, OH, United States.
Jonathan C SaxeDepartment of Medicine, Wright State University, Dayton, OH, United States; Dayton Gastroenterology, Dayton, OH, United States.
Michael BottomleyBoonshoft School of Medicine and the Statistical Consulting Center, Wright State University, Dayton, OH, United States.
Courtney E W SulenticDepartment of Pharmacology & Toxicology, Wright State University, Dayton, OH, United States. Electronic address: courtney.sulentic@wright.edu.
Wright State University · USDayton Clinical Oncology Program · US

Funding

3'alpha enhancer regulation by AhR and NF-kappaB/Rel proteinsR01ES014676 · NIEHS · WRIGHT STATE UNIVERSITY · PI SULENTIC, COURTNEY ELIZABETH WILLIAMS · 2007 to 2011
$1.4M
NIEHS NIH HHS R01 ES014676
6 · The paper itself

Abstract

backgroundGenetic and environmental factors contribute to the development of celiac disease (CD), but specific genetic predisposing factors remain poorly understood. One candidate is allele 2 of the hs1.2 enhancer within the immunoglobulin heavy chain region. In humans, there are four possible alleles and a previous study of an Italian cohort demonstrated a significantly increased frequency of allele 2 in patients with CD.

aimsThe purpose of the current study was to determine if a similar association between allele 2 and CD exists in an American population from Dayton, OH.

methodsSubjects were screened for CD via esophagogastroduodenoscopy with duodenal biopsy. All biopsies were microscopically scored using a modified Marsh-Oberhuber classification. DNA was isolated from patients' buccal cells for hs1.2 genotype analysis using PCR.

resultsUnlike the Italian cohort, allele 2 frequency was not significantly different in patients with histopathologic evidence of CD compared to patients without such evidence. However, our patient population as a whole demonstrated a significantly increased allele 2 frequency when compared to that previously reported within diverse ethnic populations.

conclusionsSince our comparative control patients do not necessarily reflect a healthy control population, an overall increase in allele 2 may reflect an association between allele 2 of the hs1.2 enhancer and a spectrum of gastrointestinal disorders.

Indexed as

Gene FrequencyAllelesBase SequenceCeliac DiseaseDuodenumEndoscopy, Digestive SystemGenetic Predisposition to DiseaseHumansImmunoglobulin Heavy ChainsOhioPolymorphism, GeneticHS1,2-A enhancer protein, humanImmunoglobulin Heavy Chains3′IGH regulatory regionAutoimmune diseaseCeliac diseaseGene regulationIg dysregulationImmunoglobulin heavy chain region (IGH)

Identifiers

PMID28473300
PMCPMC5511760
OpenAlexW2605211271

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.