Evidence map›Paper›PMID 28473238›Full record

ArticleEBioMedicine2017

Gender-related Responsiveness to the Pharmacological Treatment of COPD: A First Step Towards the Personalized Medicine.

Luigino Calzetta, Ermanno Puxeddu, Paola Rogliani

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Exploring the role of sex in asthma and COPD pharmacological treatment.Current research in pharmacology and drug discovery · 2025
    Review
  6. Review
  7. Sex, Gender, and the Regulation of Prescription Drugs: Omissions and Opportunities.International journal of environmental research and public health · 2023
    Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Luigino CalzettaDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy. Electronic address: luigino.calzetta@uniroma2.it.
Ermanno PuxedduDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Paola RoglianiDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The post-hoc analysis of the data collected from the Lung Health Study supports the evolving concept that the impact of COPD may be different between men and women, and supports the hypothesis of a gender-related responsiveness to the pharmacological treatment of COPD. Specific translational studies are needed to assess the real gender-related impact of the currently available dual bronchodilation therapy on the lung function and clinical outcomes of COPD patients. This approach may represent the first affordable step towards a feasible personalized medicine.

Indexed as

IpratropiumPulmonary Disease, Chronic ObstructiveBronchodilator AgentsFemaleHumansMaleMuscarinic AntagonistsPrecision MedicineTreatment OutcomeBronchodilator AgentsIpratropiumMuscarinic AntagonistsCOPDGenderMuscarinic receptorsPersonalized medicinePharmacological therapy

Identifiers

PMID28473238
PMCPMC5440626

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.