ArticleVeterinary research2017
Concurrent infection with porcine reproductive and respiratory syndrome virus and Haemophilus parasuis in two types of porcine macrophages: apoptosis, production of ROS and formation of multinucleated giant cells.
Article in Veterinary research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Review
- Establishment and validation of a simple and accurate qPCR detection method for Haemophilus parasuis.Scientific reports · 2025Article
- Probiotic bacteria of wild boar origin intended for piglets - AnVeterinarni medicina · 2024Article
- Fuzhengjiedu San inhibits porcine reproductive and respiratory syndrome virus by activating the PI3K/AKT pathway.PloS one · 2024Article
- Secondary Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus (HP-PRRSV2) Infection Augments Inflammatory Responses, Clinical Outcomes, and Pathogen Load inVeterinary sciences · 2023Article
- Characterization of Porcine Monocyte-Derived Macrophages Cultured in Serum-Reduced Medium.Biology · 2022Article
- PRRSV Infection Induces Gasdermin D-Driven Pyroptosis of Porcine Alveolar Macrophages through NLRP3 Inflammasome Activation.Journal of virology · 2022Article
- Study of Biological Activities and ADMET-Related Properties of Novel ChlorinatedInternational journal of molecular sciences · 2022Article
- Transcriptome profiling identifies immune response genes against porcine reproductive and respiratory syndrome virus andJournal of veterinary science · 2022Article
- Breeding for disease resilience: opportunities to manage polymicrobial challenge and improve commercial performance in the pig industry.CABI agriculture and bioscience · 2022Review
- Article
- Macrophage Polarization Modulated by Porcine Circovirus Type 2 Facilitates Bacterial Coinfection.Frontiers in immunology · 2021Article
- The Role of Antibodies Against the Crude Capsular Extract in the Immune Response of Porcine Alveolar Macrophages toFrontiers in immunology · 2021Article
- Postweaning mortality in commercial swine production II: review of infectious contributing factors.Translational animal science · 2020Review
- Fighting Cancer with Mathematics and Viruses.Viruses · 2017Review
- Global Challenges and Advancements in the Management of Pivotal Porcine/Swine Viral Diseases.In vivo (Athens, Greece)Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porcine reproductive and respiratory syndrome (PRRS) is one of the most significant and economically important infectious diseases affecting swine worldwide and can predispose pigs to secondary bacterial infections caused by, e.g. Haemophilus parasuis. The aim of the presented study was to compare susceptibility of two different types of macrophages which could be in contact with both pathogens during infection with PRRS virus (PRRSV) and in co-infection with H. parasuis. Alveolar macrophages (PAMs) as resident cells provide one of the first lines of defence against microbes invading lung tissue. On the other hand, monocyte derived macrophages (MDMs) represent inflammatory cells accumulating at the site of inflammation. While PAMs were relatively resistant to cytopathogenic effect caused by PRRSV, MDMs were much more sensitive to PRRSV infection. MDMs infected with PRRSV increased expression of pro-apoptotic Bad, Bax and p53 mRNA. Increased mortality of MDMs may be also related to a higher intensity of ROS production after infection with PRRSV. In addition, MDMs (but not PAMs) infected with H. parasuis alone formed multinucleated giant cells (MGC); these cells were not observed in MDMs infected with both pathogens. Higher sensitivity of MDMs to PRRSV infection, which is associated with limited MDMs survival and restriction of MGC formation, could contribute to the development of multifactorial respiratory disease of swine.
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