ArticleBMC psychiatry2017
Pain severity predicts depressive symptoms over and above individual illnesses and multimorbidity in older adults.
Article in BMC psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05194722 (Optimizing Implementation of Mental Health Intervention Within Orthopedic Care), which is not on this map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimizing Implementation of Mental Health Intervention Within Orthopedic Care
Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Design Preferences for Mental Health Apps Among Nondigitally Native Adults With Chronic Pain: Qualitative Analysis.JMIR mHealth and uHealth · 2026Article
- Optimizing Usability of Digital Health Interventions for Nondigitally Native Adults: A Framework-Based Approach to Develop Just-in-Time Adaptive Interventions (JITAIs) and Other Adaptations.JMIR human factors · 2026Article
- Iterating the women in pain reduction and improved mood through empowerment intervention.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Two-years clinical course of pain intensity and symptom satisfaction for latent classes in older adults with back pain.BMC musculoskeletal disorders · 2025Observational
- The chain mediating effects of somatic pain and depression between chronic diseases and sleep in the older patients.Sleep & breathing = Schlaf & Atmung · 2025Article
- Article
- Evaluating and Optimizing Just-in-Time Adaptive Interventions in a Digital Mental Health Intervention (Wysa for Chronic Pain) for Middle-Aged and Older Adults With Chronic Pain: Protocol for a Series of Randomized Trials.JMIR research protocols · 2025Article
- Article
- History of chronic pain and opioid use is associated with cognitive decline and mild cognitive impairment.Journal of the International Neuropsychological Society : JINS · 2025Article
- Depression and comorbid chronic physical health diseases in the Australian population: A scoping review.The Australian and New Zealand journal of psychiatry · 2025Article
- Longitudinal relationship between adverse childhood experiences and depressive symptoms: the mediating role of physical pain.BMC psychiatry · 2024Article
- Association between Migraine and Quality of Life, Mental Health, Sleeping Disorders, and Health Care Utilization Among Older African American Adults.Journal of racial and ethnic health disparities · 2024Article
- Long non-coding RNA MSTRG.81401 short hairpin RNA relieves diabetic neuropathic pain and behaviors of depression by inhibiting P2X4 receptor expression in type 2 diabetic rats.Purinergic signalling · 2023Article
- Chronic disease and depression among the elderly in China: the mediating role of instrumental activities of daily living and the moderating role of area of residence.Current psychology (New Brunswick, N.J.) · 2022Article
- Prevalence and factors associated with the depressive symptoms in rural and urban Mexican older adults: evidence from the Mexican Health and Aging Study 2018.Salud publica de Mexico · 2022Article
- Childhood adversities and the comorbidity between mood and general medical disorders in adults: Results from the WHO World Mental Health Survey Portugal.Brain, behavior, & immunity - health · 2021Article
- Interoceptive attention regulation in Ehlers-Danlos syndromes: associations between pain and psychiatric symptom severity.Translational behavioral medicine · 2021Article
- Associations between physical multimorbidity patterns and common mental health disorders in middle-aged adults: A prospective analysis using data from the UK Biobank.The Lancet regional health. Europe · 2021Article
- Multi-Dimensional Impact of Chronic Low Back Pain among Underserved African American and Latino Older Adults.International journal of environmental research and public health · 2021Article
- SymTrak-8 as a Brief Measure for Assessing Symptoms in Older Adults.Journal of general internal medicine · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMulti-morbidity in older adults is commonly associated with depressed mood. Similarly, subjective reports of pain are also associated with both physical illness and increased depressive symptoms. However, whether pain independently contributes to the experience of depression in older people with multi-morbidity has not been studied.
methodsIn this study, participants were 1281 consecutive older adults presenting to one of 19 primary care services in Australia (recruitment rate = 75%). Participants were asked to indicate the presence of a number of common chronic illnesses, to rate their current pain severity and to complete the Geriatric Depression Scale.
resultsResults confirmed that the number of medical illnesses reported was strongly associated with depressive symptoms. Twenty-six percent of participants with multi-morbidity scored in the clinical range for depressive symptoms in comparison to 15% of participants with no illnesses or a single illness. In regression analyses, the presence of chronic pain (t = 5.969, p < 0.0005), diabetes (t = 4.309, p < 0.0005), respiratory (t = 3.720, p < 0.0005) or neurological illness (t = 2.701, p = 0.007) were all independent contributors to depressive symptoms. Even when controlling for each individual illness, and the overall number of illnesses (t = 2.207, p = 0.028), pain severity remained an independent predictor of depressed mood (F change = 28.866, p < 0.0005, t = 5.373, p < 0.0005).
conclusionsPhysicians should consider screening for mood problems amongst those with multi-morbidity, particularly those who experience pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.