ArticleNeuron2017
Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 118 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed, 225 citations in OpenAlex.
- Ternary Neurexin-T178-PTPR complexes represent a pre-synaptic core-module of neuronal synapse organization.Nature communications · 2026Article
- Synaptic Ca2+ channels and neurexins are linked through direct and indirect binding complexes.Scientific reports · 2026Article
- Intracellular protein-lipid interactions drive presynaptic assembly prior to neurexin recruitment.Neuron · 2025Article
- Stepwise molecular specification of excitatory synapse diversity onto cerebellar Purkinje cells.Nature neuroscience · 2025Article
- Glutamate Signaling and Neuroligin/Neurexin Adhesion Play Opposing Roles That Are Mediated by Major Histocompatibility Complex I Molecules in Cortical Synapse Formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Conserved autism-associated genes tune social feeding behavior in C. elegans.Nature communications · 2024Article
- Differential roles of lysosomal cholesterol transporters in the development ofLife science alliance · 2024Article
- Distinct active zone protein machineries mediate CaNature neuroscience · 2024Article
- Exposure to Radiofrequency Induces Synaptic Dysfunction in Cortical Neurons Causing Learning and Memory Alteration in Early Postnatal Mice.International journal of molecular sciences · 2024Article
- Monoallelic de novoScience advances · 2024Article
- Article
- MDGAs perform activity-dependent synapse type-specific suppression via distinct extracellular mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Decoding transcriptomic signatures of cysteine string protein alpha-mediated synapse maintenance.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Essential Role of Latrophilin-1 Adhesion GPCR Nanoclusters in Inhibitory Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic CaCells · 2024Article
- Neurexins control the strength and precise timing of glycinergic inhibition in the auditory brainstem.eLife · 2024Article
- Conditional deletion of neurexin-2 impaired behavioral flexibility to alterations in action-outcome contingency.Scientific reports · 2024Article
- Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold.Cold Spring Harbor perspectives in biology · 2024Review
- Structural neuroplasticity after sleep loss modifies behavior and requires neurexin and neuroligin.iScience · 2024Article
- Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
- Correction · 2024-06-05Error in Image · Updated to Retraction · · see also https://pubpeer.com/publications/F7C42C356B2E7049FDB68A434EF4F8; correction retracted separately: DOI:10.1016/j.neuron.2025.01.027;
- Retraction · 2025-02-19Concerns/Issues about Image · Investigation by Third Party · Original Data and/or Images not Provided and/or not Available · Upgrade/Update of Prior Notice(s) · · see also https://pubpeer.com/publications/F7C42C356B2E7049FDB68A434EF4F8; correction retracted separately: DOI:10.1016/j.neuron.2025.01.027;
- Erratum issued
- Retracted
- Update of
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Neurexins are recognized as key organizers of synapses that are essential for normal brain function. However, it is unclear whether neurexins are fundamental building blocks of all synapses with similar overall functions or context-dependent specifiers of synapse properties. To address this question, we produced triple cKO (conditional knockout) mice that allow ablating all neurexin expression in mice. Using neuron-specific manipulations combined with immunocytochemistry, paired recordings, and two-photon Ca
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.