ArticlePathogens and disease2017
Spatial clustering of high load ocular Chlamydia trachomatis infection in trachoma: a cross-sectional population-based study.
Article in Pathogens and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Community-level trachoma ecological associations and the use of geospatial analysis methods: A systematic review.PLoS neglected tropical diseases · 2022Pooled it
- Safety of azithromycin in infants under six months of age in Niger: A community randomized trial.PLoS neglected tropical diseases · 2018Trial
- Mass azithromycin distribution for hyperendemic trachoma following a cluster-randomized trial: A continuation study of randomly reassigned subclusters (TANA II).PLoS medicine · 2018Trial
- Comparative transcriptomic profiling of human conjunctival epithelial cells and macrophages in response toFrontiers in cellular and infection microbiology · 2026Article
- Prevalence and spatial distributions of trachomatous inflammation-follicular among children aged 1-9 years in rural areas of Yilmana Densa and Gonji Kolela districts, Northwestern Ethiopia.BMC public health · 2025Article
- Evolutionary dynamics in the genome of ocularMicrobial genomics · 2025Article
- Field- and laboratory-based studies on correlates of Chlamydia trachomatis transmission by Musca sorbens: Determinants of fly-eye contact and investigations into fly carriage of elementary bodies.PLoS neglected tropical diseases · 2024Article
- Genomic insights into local-scale evolution of ocularMicrobial genomics · 2024Article
- Modelling morbidity for neglected tropical diseases: the long and winding road from cumulative exposure to long-term pathology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Predicting future community-level ocular Chlamydia trachomatis infection prevalence using serological, clinical, molecular, and geospatial data.PLoS neglected tropical diseases · 2022Article
- Surveillance for peri-elimination trachoma recrudescence: Exploratory studies in Ghana.PLoS neglected tropical diseases · 2021Article
- Acceptability and perceived utility of different diagnostic tests and sample types for trachoma surveillance in the Bijagos Islands, Guinea Bissau.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2021Article
- Comparison of genovars and Chlamydia trachomatis infection loads in ocular samples from children in two distinct cohorts in Sudan and Morocco.PLoS neglected tropical diseases · 2021Article
- Modelling trachoma post-2020: opportunities for mitigating the impact of COVID-19 and accelerating progress towards elimination.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2021Article
- Identification of potential lockdown areas during COVID-19 transmission in Punjab, Pakistan.Public health · 2021Article
- The simplified trachoma grading system, amended.Bulletin of the World Health Organization · 2020Article
- Prevalence and associations of active trachoma among rural preschool children in Wadla district, northern Ethiopia.BMC ophthalmology · 2020Article
- Serological and PCR-based markers of ocular Chlamydia trachomatis transmission in northern Ghana after elimination of trachoma as a public health problem.PLoS neglected tropical diseases · 2018Article
- Population-based analysis of ocular Chlamydia trachomatis in trachoma-endemic West African communities identifies genomic markers of disease severity.Genome medicine · 2018Article
- The impact of a single round of community mass treatment with azithromycin on disease severity and ocular Chlamydia trachomatis load in treatment-naïve trachoma-endemic island communities in West Africa.Parasites & vectors · 2017Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Chlamydia trachomatis (Ct) is the most common cause of bacterial sexually transmitted infection and infectious cause of blindness (trachoma) worldwide. Understanding the spatial distribution of Ct infection may enable us to identify populations at risk and improve our understanding of Ct transmission. In this study, we sought to investigate the spatial distribution of Ct infection and the clinical features associated with high Ct load in trachoma-endemic communities on the Bijagós Archipelago (Guinea Bissau). We collected 1507 conjunctival samples and corresponding detailed clinical data during a cross-sectional population-based geospatially representative trachoma survey. We used droplet digital PCR to estimate Ct load on conjunctival swabs. Geostatistical tools were used to investigate clustering of ocular Ct infections. Spatial clusters (independent of age and gender) of individuals with high Ct loads were identified using local indicators of spatial association. We did not detect clustering of individuals with low load infections. These data suggest that infections with high bacterial load may be important in Ct transmission. These geospatial tools may be useful in the study of ocular Ct transmission dynamics and as part of trachoma surveillance post-treatment, to identify clusters of infection and thresholds of Ct load that may be important foci of re-emergent infection in communities.
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