ArticleNucleic acids research2017
PIGSPro: prediction of immunoGlobulin structures v2.
Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Comparative assessment of different anti-CD147/Basigin 2 antibodies as a potential therapeutic anticancer target by molecular modeling and dynamic simulation.Molecular diversity · 2025Article
- The ClusPro AbEMap web server for the prediction of antibody epitopes.Nature protocols · 2023Review
- Structure-Based Optimization of Antibody-Based Biotherapeutics for Improved Developability: A Practical Guide for Molecular Modelers.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Structural Modeling of Adaptive Immune Responses to Infection.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Computational Modeling of Antibody and T-Cell Receptor (CDR3 Loops).Methods in molecular biology (Clifton, N.J.) · 2023Article
- Characterization of Neutralizing Human Anti-Tetanus Monoclonal Antibodies Produced by Stable Cell Lines.Pharmaceutics · 2022Article
- Antigen binding by conformational selection in near-germline antibodies.The Journal of biological chemistry · 2022Article
- Functional antibody characterization via direct structural analysis and information-driven protein-protein docking.Proteins · 2022Article
- VInternational journal of molecular sciences · 2022Review
- Shape Complementarity Optimization of Antibody-Antigen Interfaces: The Application to SARS-CoV-2 Spike Protein.Frontiers in molecular biosciences · 2022Article
- Insights into Comparative Modeling of VInternational journal of molecular sciences · 2021Article
- Systematic Structure-Based Virtual Screening Approach to Antibody Selection and Design of a Humanized Antibody against Multiple Addictive Opioids without Affecting Treatment Agents Naloxone and Naltrexone.ACS chemical neuroscience · 2021Article
- Robustification of RosettaAntibody and Rosetta SnugDock.PloS one · 2021Article
- Quantitative Description of Surface Complementarity of Antibody-Antigen Interfaces.Frontiers in molecular biosciences · 2021Article
- Immunoglobulin Classification Based on FC* and GC* Features.Frontiers in genetics · 2021Article
- Quality Assessment of Protein Docking Models Based on Graph Neural Network.Frontiers in bioinformatics · 2021Article
- Computational Investigation of Gantenerumab and Crenezumab Recognition of Aβ Fibrils in Alzheimer's Disease Brain Tissue.ACS chemical neuroscience · 2020Article
- Biomedical Science to Tackle the COVID-19 Pandemic: Current Status and Future Perspectives.Molecules (Basel, Switzerland) · 2020Review
- Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Convergent Evolution in Breadth of Two VCell host & microbe · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PIGSpro is a significant upgrade of the popular PIGS server for the prediction of the structure of immunoglobulins. The software has been completely rewritten in python following a similar pipeline as in the original method, but including, at various steps, relevant modifications found to improve its prediction accuracy, as demonstrated here. The steps of the pipeline include the selection of the appropriate framework for predicting the conserved regions of the molecule by homology; the target template alignment for this portion of the molecule; the selection of the main chain conformation of the hypervariable loops according to the canonical structure model, the prediction of the third loop of the heavy chain (H3) for which complete canonical structures are not available and the packing of the light and heavy chain if derived from different templates. Each of these steps has been improved including updated methods developed along the years. Last but not least, the user interface has been completely redesigned and an automatic monthly update of the underlying database has been implemented. The method is available as a web server at http://biocomputing.it/pigspro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.