ArticleThe Journal of clinical endocrinology and metabolism2017
Maturation in Serum Thyroid Function Parameters Over Childhood and Puberty: Results of a Longitudinal Study.
Article in The Journal of clinical endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Muscle strength, muscle morphology, and oxidative capacity in normal weight versus overweight and obese youth: a systematic review with meta-analysis.Scientific reports · 2025Pooled it
- Epigenome-Wide Association Study of Thyroid Function Traits Identifies Novel Associations of fT3 With KLF9 and DOT1L.The Journal of clinical endocrinology and metabolism · 2021Pooled it
- Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.Thyroid : official journal of the American Thyroid Association · 2021Guideline
- Clinical Characteristics and Thyroid Findings in Children with Isolated Premature Adrenarche.Children (Basel, Switzerland) · 2026Article
- Validation of Immunoassays for Total Thyroxine and Free Thyroxine and Age and Sex-Related Variation in Thyroid Hormone Serum Concentrations in Orangutans (Pongo sp.).Journal of medical primatology · 2026Article
- Iodine deficiency in the first pregnancy trimester and intelligence in adolescence.European journal of nutrition · 2026Article
- Chemical-enhanced thyroid cell detection using photonic crystal biosensors with phase-change materials.RSC advances · 2026Article
- Thyroid dysfunction in ageing populations.Endocrine connections · 2025Review
- Effects of childhood and adult height on later life cardiovascular disease risk estimated through Mendelian randomization.European journal of epidemiology · 2025Article
- Neonatal reference intervals for thyroid stimulating hormone and free thyroxine assayed on a Siemens Atellica® IM analyzer: a cross sectional study.BMC endocrine disorders · 2023Article
- Age-related variation in thyroid function - a narrative review highlighting important implications for research and clinical practice.Thyroid research · 2023Review
- Persistent Organic Pollutant Exposure and Thyroid Function among 12-Year-Old Children.Neuroendocrinology · 2023Article
- Congenital hypothyroidism and thyroid function in a Japanese birth cohort: data from The Japan Environment and Children's Study.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2023Article
- Possible Association Between Thyroid Nodule Formation and Developmental Alterations in the Pituitary-Thyroid Hormone Axis in Children and Adolescents: The Fukushima Health Management Survey.Thyroid : official journal of the American Thyroid Association · 2022Article
- Free triiodothyronine/free thyroxine ratio in children with congenital hypothyroidism.Endocrine connections · 2022Article
- Inherited Selenocysteine Transfer RNA Mutation: Clinical and Hormonal Evaluation of 2 Patients.European thyroid journal · 2021Article
- Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.European thyroid journal · 2021Article
- Thyroid Function Changes and Pubertal Progress in Females: A Longitudinal Study in Iodine-Sufficient Areas of East China.Frontiers in endocrinology · 2021Article
- Hypothyroidism after radiation exposure: brief narrative review.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- The association between thyroid function biomarkers and attention deficit hyperactivity disorder.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
19 authors at 8 institutions in 1 country.
Funding
Abstract
Context: Serum thyroid hormone levels differ between children and adults, but have not been studied longitudinally through childhood. Objective: To assess changes in thyroid-stimulating hormone (TSH) and thyroid hormone levels over childhood and their interrelationships. Design: Cohort study. Setting: The Avon Longitudinal Study of Parents and Children, a population-based birth cohort. Participants: A total of 4442 children who had thyroid function measured at age 7, and 1263 children who had thyroid function measured at age 15. Eight hundred eighty-four children had measurements at both ages. Main Outcome Measures: Reference ranges for TSH, free tri-iodothyronine (FT3), free thyroxine (FT4), their longitudinal stability, and interrelationships. Results: Children at age 7 years had a higher FT3 [6.17 pmol/L, standard deviation (SD) 0.62] than children at age 15 (5.83 pmol/L, SD 0.74); P < 0.0001 with 23.2% of children at age 7 having FT3 above the adult reference range. Higher FT3 levels at age 7 in boys (P = 0.0001) and girls (P = 0.04) were associated with attainment of a more advanced pubertal stage at age 13. TSH was positively associated with FT3 at age 7 and age 15 even after adjusting for confounders. In contrast, TSH was negatively associated with FT4. Conclusions: There are substantial changes in TSH and thyroid hormone levels over childhood, in particular for FT3, which appear to relate to pubertal readiness. Our data provide increased insight into the evolution of the pituitary-thyroid axis over childhood and may have implications for determining optimal ranges for thyroid hormone replacement in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.