ArticleGenome biology and evolution2017
Contrasting Sex-and Caste-Dependent piRNA Profiles in the Transposon Depleted Haplodiploid Honeybee Apis mellifera.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Evolution of piRNA-guided defense against transposable elements.Trends in genetics : TIG · 2025Review
- The eusocial non-code: Unveiling the impact of noncoding RNAs on Hymenoptera eusocial evolution.Non-coding RNA research · 2025Review
- Analysis of the Expression Patterns of piRNAs in Response to Microsporidian Invasion in Midgut of Workers (International journal of molecular sciences · 2025Article
- Non-gonadal expression of piRNAs is widespread across Arthropoda.FEBS letters · 2025Review
- Acute bee paralysis virus regulation of microRNA expression dynamics in the insect host (Frontiers in cellular and infection microbiology · 2025Article
- Embryonic piRNAs target horizontally transferred vertebrate transposons in assassin bugs.Frontiers in cell and developmental biology · 2024Article
- Review
- First Identification and Investigation of piRNAs in the Larval Gut of the Asian Honeybee,Insects · 2022Article
- Abundant small RNAs in the reproductive tissues and eggs of the honey bee, Apis mellifera.BMC genomics · 2022Article
- Genome architecture and social evolution.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Transcriptomic and functional analyses of the piRNA pathway in the Chagas disease vector Rhodnius prolixus.PLoS neglected tropical diseases · 2018Article
- Detecting rare asymmetrically methylated cytosines and decoding methylation patterns in the honeybee genome.Royal Society open science · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protecting genome integrity against transposable elements is achieved by intricate molecular mechanisms involving PIWI proteins, their associated small RNAs (piRNAs), and epigenetic modifiers such as DNA methylation. Eusocial bees, in particular the Western honeybee, Apis mellifera, have one of the lowest contents of transposable elements in the animal kingdom, and, unlike other animals with a functional DNA methylation system, appear not to methylate their transposons. This raises the question of whether the PIWI machinery has been retained in this species. Using comparative genomics, mass spectrometry, and expressional profiling, we present seminal evidence that the piRNA system is conserved in honeybees. We show that honey bee piRNAs contain a 2'-O-methyl modification at the 3' end, and have a bias towards a 5' terminal U, which are signature features of their biogenesis. Both piRNA repertoire and expression levels are greater in reproductive individuals than in sterile workers. Haploid males, where the detrimental effects of transposons are dominant, have the greatest piRNA levels, but surprisingly, the highest expression of transposons. These results show that even in a transposon-depleted species, the piRNA system is required to guard the vulnerable haploid genome and reproductive castes against transposon-associated genomic instability. This also suggests that dosage plays an important role in the regulation of transposons and piRNAs expression in haplo-diploid systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.