Evidence map›Paper›PMID 28472304›Full record

ArticleEndocrinology2017

Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature.

Frédéric Flamant, Sheue-Yann Cheng, Anthony N Hollenberg, Lars C Moeller, Jacques Samarut, Fredric E Wondisford, Paul M Yen, Samuel Refetoff

Abstract read
In one paragraph

Article in Endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. JBMR plus · 2026
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  10. Overlapping action of TFrontiers in endocrinology · 2024
    Article
  11. Review
  12. Article
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  15. Thyroid Axis and Vestibular Physiopathology: From Animal Model to Pathology.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Frédéric FlamantInstitut de Génomique Fonctionnelle de Lyon, INRA USC 1370, Université de Lyon, Université Lyon 1, CNRS UMR 5242, Ecole Normale Supérieure de Lyon, 69364 Lyon cedex 07, France.
Sheue-Yann ChengGene Regulation Section, Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-6264.
Anthony N HollenbergDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215.
Lars C MoellerDivision of Laboratory Research, Department of Endocrinology and Metabolic Diseases, University of Duisburg-Essen, 45127 Essen, Germany.
Jacques SamarutInstitut de Génomique Fonctionnelle de Lyon, INRA USC 1370, Université de Lyon, Université Lyon 1, CNRS UMR 5242, Ecole Normale Supérieure de Lyon, 69364 Lyon cedex 07, France.
Fredric E WondisfordDepartment of Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903.
Paul M YenLaboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, 169857, Singapore.
Samuel RefetoffDepartment of Medicine, University of Chicago, Chicago, Illinois 60637.

Funding

Thyroid Hormone Receptors in Health and DiseaseZIABC008752 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHENG, SHEUE-YANN · 2009 to 2025
$12.9M
THYROID PHYSIOLOGY STUDIES OF INHERITED DISORDERSR01DK015070 · NIDDK · UNIVERSITY OF CHICAGO · PI ANTONIO C BIANCO, Alexandra Mihaela Dumitrescu · 1986 to 2026
$8.1M
NIDDK NIH HHS R01 DK015070
6 · The paper itself

Abstract

Current literature makes a distinction between two pathways for thyroid hormone signaling: genomic and nongenomic. However, this classification is a source of confusion. We propose a clarification in the nomenclature that may help to avoid unproductive controversies and favor progress in this field of research. Four types of thyroid hormone signaling are defined, and the experimental criteria for classification are discussed.

Indexed as

Terminology as TopicAnimalsDNAHumansReceptors, Thyroid HormoneSignal TransductionThyroid HormonesTranscription FactorsDNAReceptors, Thyroid HormoneThyroid HormonesTranscription Factors

Identifiers

PMID28472304
PMCPMC6283428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.