Evidence map›Paper›PMID 28472238›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2018

Do Female Dogs Age Differently Than Male Dogs?

Jessica M Hoffman, Dan G O'Neill, Kate E Creevy, Steven N Austad

Abstract read
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Cutaneous mast cell tumors in dogs: Association with gonadectomy.Brazilian journal of veterinary medicine · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. MicroRNA Expression Variation in Female Dog (Animals : an open access journal from MDPI · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Alterations of Lipid Metabolism With Age and Weight in Companion Dogs.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
  14. Review
  15. Reproductive Suicide: Similar Mechanisms of Aging inFrontiers in cell and developmental biology · 2021
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jessica M HoffmanDepartment of Biology, University of Alabama at Birmingham.
Dan G O'NeillDepartment of Pathobiology and Population Science, The Royal Veterinary College, Hatfield, UK.
Kate E CreevyDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station.
Steven N AustadDepartment of Biology, University of Alabama at Birmingham.

Funding

Sex hormones and arthritis in a long lived animal modelP30AG050886 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DAVID B ALLISON · 2015 to 2026
$11.3M
NIA NIH HHS P30 AG050886
6 · The paper itself

Abstract

Humans, as well as their closest ancestors, the higher African primates, exhibit female-biased survival and multiple sex differences in causes of death. However, the effects of sex on aging and longevity in an excellent model of human health, the companion dog, have not been well explored. Using two large independent databases on companion dog longevity and causes of death, we performed the most extensive analysis of sex differences in dog aging to date. Unlike the findings in humans, we observed only a small effect of sex on canine longevity. When broken down by neutering status, we discovered a small male advantage in survival among intact dogs but a clear female survival advantage among neutered dogs. Overall, the effect of neutering on life span was greater than the effect of sex. However, we found few sex differences in causes of death in either intact or neutered dogs. The results of this study suggest limited sex effects on either longevity or causes of death in the companion dog. Our analysis suggests that the majority of apparent sex differences in the wider canine populations may be due to the effects of neutering.

Indexed as

Sex CharacteristicsAgingAnimalsCastrationDogsFemaleLongevityMaleRetrospective StudiesSex FactorsCause of deathLife spanNeuteringSex differencesVetCompassVMBD

Identifiers

PMID28472238
PMCPMC5861885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.