Evidence map›Paper›PMID 28472225›Full record

ArticleAmerican journal of epidemiology2017

Association of Recent Bacterial Vaginosis With Acquisition of Mycoplasma genitalium.

Erica M Lokken, Jennifer E Balkus, James Kiarie, James P Hughes, Walter Jaoko, Patricia A Totten, R Scott McClelland, Lisa E Manhart

Open access · bronzeAbstract read
In one paragraph

Article in American journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Sexually Transmitted Infections Treatment Guidelines, 2021.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021
    Guideline
  2. Sexually transmitted infections · 2019
    Pooled it
  3. Trial
  4. Trial
  5. Mycoplasma genitalium Infection in Kenyan and US Women.Sexually transmitted diseases · 2018
    Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Mycoplasma genitalium in the US (MyGeniUS): Surveillance Data From Sexual Health Clinics in 4 US Regions.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Bacterial Vaginosis and Post-Operative Pelvic Infections.Healthcare (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Erica M Lokken
Jennifer E Balkus
James Kiarie
James P Hughes
Walter Jaoko
Patricia A Totten
R Scott McClelland
Lisa E Manhart
University of Washington · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Vaginal Health and the Risk of HIV-1 Acquistion in Kenyan WomenP01HD064915 · NICHD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI OVERBAUGH, JULIE M. · 2009 to 2013
$8.9M
Impact of suppressive antimicrobial therapy on the vaginal microbiota and BVR01AI099106 · NIAID · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, RAYMOND SCOTT · 2012 to 2014
$1.8M
NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI099106NICHD NIH HHS P01 HD064915
6 · The paper itself

Abstract

We assessed the association between recent bacterial vaginosis (BV) and incident Mycoplasma genitalium, a sexually transmitted bacterium associated with adverse female reproductive health outcomes. Female sex workers in Mombasa, Kenya, completed a monthly sexual behavior interview and clinical examination. During February 2005-February 2006, vaginal fluid specimens collected from women every other month were tested for M. genitalium by nucleic acid amplification testing. Vaginal microbiota were assessed monthly and categorized by Nugent score (0-3 = normal microbiota, 4-6 = intermediate microbiota disruption, and 7-10 = BV). A discrete failure time analysis for multiple events using logistic regression was employed to estimate the odds of incident M. genitalium infection at follow-up visits among women with BV (vs. normal microbiota) at the preceding visit. Among the 280 women, 54.3% were positive for human immunodeficiency virus. At baseline, 16.1% had prevalent M. genitalium infection and 40.4% had prevalent BV. There were 59 incident M. genitalium infections among 50 women, for an incidence rate of 34.6 cases per 100 person-years. Following adjustment for age, human immunodeficiency virus status, and time, prior BV was associated with a 3.5-fold increase in odds of incident M. genitalium (adjusted odds ratio = 3.49, 95% confidence interval: 1.86, 6.56). This strong association suggests that BV may enhance susceptibility to M. genitalium infection.

Indexed as

AdultComorbidityFemaleHIV InfectionsHumansIncidenceKenyaMycoplasma genitaliumPrevalenceProspective StudiesReproductive HealthRisk FactorsSexual BehaviorSexually Transmitted DiseasesSex WorkersVaginabacterial vaginosisMycoplasma genitaliumNugent scorevaginal microbiota

Identifiers

PMID28472225
PMCPMC5860020
OpenAlexW2610700650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.