ArticlePLoS genetics2017
The highly buffered Arabidopsis immune signaling network conceals the functions of its components.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- A Meta-Analysis Reveals Opposite Effects of Biotic and Abiotic Stresses on Transcript Levels of Arabidopsis Intracellular Immune Receptor Genes.Frontiers in plant science · 2021Pooled it
- Role of the Genetic Background in Resistance to Plant Viruses.International journal of molecular sciences · 2018Pooled it
- Cell-type-specific gating of gene regulatory modules as a hallmark of early immune responses in Arabidopsis leaves.The New phytologist · 2026Article
- Decoding plant defense signaling using the defenseless mutant.The New phytologist · 2026Article
- From gene-for-gene to NLRome-for-effectorome: decoding the dynamic interplay between phytopathogenic effector networks and plant immune systems.FEMS microbiology reviews · 2026Review
- Proteomic snapshot of pattern triggered immunity in the Arabidopsis leaf apoplast.The Plant journal : for cell and molecular biology · 2025Article
- Neutral transcriptome rewiring promotes quantitative disease resistance evolvability at the species level.The Plant cell · 2025Article
- An effector essential for virulence of necrotrophic fungi targets plant HIRs to inhibit host immunity.Nature communications · 2024Article
- Transporter-mediated depletion of extracellular proline directly contributes to plant pattern-triggered immunity against a bacterial pathogen.Nature communications · 2024Article
- Decomposition of dynamic transcriptomic responses during effector-triggered immunity reveals conserved responses in two distinct plant cell populations.Plant communications · 2024Article
- Genomic overview of INA-induced NPR1 targeting and transcriptional cascades in Arabidopsis.Nucleic acids research · 2024Article
- Systemic analysis of metabolome reconfiguration in Arabidopsis after abiotic stressors uncovers metabolites that modulate defense against pathogens.Plant communications · 2024Article
- An averaging model for analysis and interpretation of high-order genetic interactions.PloS one · 2024Article
- Changing turn-over rates regulate abundance of tryptophan, GS biosynthesis, IAA transport and photosynthesis proteins in Arabidopsis growth defense transitions.BMC biology · 2023Article
- Plant extracellular self-DNA inhibits growth and induces immunity via the jasmonate signaling pathway.Plant physiology · 2023Article
- Tissue-Specific Hormone Signalling and Defence Gene Induction in an In Vitro Assembly of the RapeseedInternational journal of molecular sciences · 2023Article
- Linking plant functional genes to rhizosphere microbes: a review.Plant biotechnology journal · 2023Review
- Amino acid motifs for the identification of novel protein interactants.Computational and structural biotechnology journal · 2023Review
- Dissecting the cotranscriptome landscape of plants and their microbiota.EMBO reports · 2022Article
- Dynamic enhancer transcription associates with reprogramming of immune genes during pattern triggered immunity in Arabidopsis.BMC biology · 2022Article
Corrections and comments
- Commented on by
Authors and funding
10 authors at 3 institutions in 4 countries.
Funding
Abstract
Plant immunity protects plants from numerous potentially pathogenic microbes. The biological network that controls plant inducible immunity must function effectively even when network components are targeted and disabled by pathogen effectors. Network buffering could confer this resilience by allowing different parts of the network to compensate for loss of one another's functions. Networks rich in buffering rely on interactions within the network, but these mechanisms are difficult to study by simple genetic means. Through a network reconstitution strategy, in which we disassemble and stepwise reassemble the plant immune network that mediates Pattern-Triggered-Immunity, we have resolved systems-level regulatory mechanisms underlying the Arabidopsis transcriptome response to the immune stimulant flagellin-22 (flg22). These mechanisms show widespread evidence of interactions among major sub-networks-we call these sectors-in the flg22-responsive transcriptome. Many of these interactions result in network buffering. Resolved regulatory mechanisms show unexpected patterns for how the jasmonate (JA), ethylene (ET), phytoalexin-deficient 4 (PAD4), and salicylate (SA) signaling sectors control the transcriptional response to flg22. We demonstrate that many of the regulatory mechanisms we resolved are not detectable by the traditional genetic approach of single-gene null-mutant analysis. Similar to potential pathogenic perturbations, null-mutant effects on immune signaling can be buffered by the network.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.