ArticlePloS one2017
A novel finite element model of the ovine lumbar intervertebral disc with anisotropic hyperelastic material properties.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Ovine models of intervertebral disc degeneration.Annals of translational medicine · 2025Review
- Review
- Investigation of the Role of Osteoporotic Vertebra Degeneration on the Stability of the Lumbar Spine: In Silico Modelling under Compressive Loading.Bioengineering (Basel, Switzerland) · 2024Article
- The Sheep as a Large Animal Model for the Investigation and Treatment of Human Disorders.Biology · 2022Review
- AnFrontiers in bioengineering and biotechnology · 2022Article
- Spinal stability analysis of lumbar interbody fusion according to pelvic type and cage angle based on simplified spinal model with various pelvic indices.Frontiers in bioengineering and biotechnology · 2022Article
- Quantitative MRI to Characterize the Nucleus Pulposus Morphological and Biomechanical Variation According to Sagittal Bending Load and Radial Fissure, anFrontiers in bioengineering and biotechnology · 2021Article
- Experimental and Computational Comparison of Intervertebral Disc Bulge for Specimen-Specific Model Evaluation Based on Imaging.Frontiers in bioengineering and biotechnology · 2021Article
- Mechanical and biological characterization of a composite annulus fibrosus repair strategy in an endplate delamination model.JOR spine · 2020Article
- The Quantitative Structural and Compositional Analyses of Degenerating Intervertebral Discs Using Magnetic Resonance Imaging and Contrast-Enhanced Micro-Computed Tomography.Annals of biomedical engineering · 2017Article
- Annulus fibrosus functional extrafibrillar and fibrous mechanical behaviour: experimental and computational characterisation.Royal Society open science · 2017Article
- Numerical Prediction of the Mechanical Failure of the Intervertebral Disc under Complex Loading Conditions.Materials (Basel, Switzerland) · 2017Article
- Finite element comparison between the human and the ovine lumbar intervertebral disc.Muscles, ligaments and tendons journalArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ovine spine is an accepted model to investigate the biomechanical behaviour of the human lumbar one. Indeed, the use of animal models for in vitro studies is necessary to investigate the mechanical behaviour of biological tissue, but needs to be reduced for ethical and social reasons. The aim of this study was to create a finite element model of the lumbar intervertebral disc of the sheep that may help to refine the understanding of parallel in vitro experiments and that can be used to predict when mechanical failure occurs. Anisotropic hyperelastic material properties were assigned to the annulus fibrosus and factorial optimization analyses were performed to find out the optimal parameters of the ground substance and of the collagen fibers. For the ground substance of the annulus fibrosus the investigation was based on experimental data taken from the literature, while for the collagen fibers tensile tests on annulus specimens were conducted. Flexibility analysis in flexion-extension, lateral bending and axial rotation were conducted. Different material properties for the anterior, lateral and posterior regions of the annulus were found. The posterior part resulted the stiffest region in compression whereas the anterior one the stiffest region in tension. Since the flexibility outcomes were in a good agreement with the literature data, we considered this model suitable to be used in conjunction with in vitro and in vivo tests to investigate the mechanical behaviour of the ovine lumbar disc.
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