ArticlePloS one2017
Transcriptome analysis of muskrat scented glands degeneration mechanism.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Multi-omics unravels testis-regulated genetic mechanism of musk secretion in muskrat (Ondatra zibethicus).BMC genomics · 2026Article
- Histological and histochemical characterization of the musk gland in forest musk deer (European journal of histochemistry : EJH · 2025Article
- Caspase-8-and Gasdermin D (GSDMD)-Dependent PANoptosis Participate in the Seasonal Atrophy of Scented Glands in Male Muskrats.Animals : an open access journal from MDPI · 2024Article
- Article
- Regulatory Roles of Peroxisomal Metabolic Pathways Involved in Musk Secretion in Muskrats.The Journal of membrane biology · 2019Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The scented gland, a musk-secreting organ of male muskrats, shows clear seasonal changes. When entering the secreting season in March, scented glands gradually increase in size and active secretion starts. In September, scented glands become gradually smaller and secretion decreases. By November, scented glands are gradually replaced by adipose tissue. In this study, six healthy adult male muskrats were analysed: three from the secreting season (March) and three from the non-secreting season (November). Using RNA-Seq analysis, gene expression profiles of scented glands from both seasons were determined. Using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, we found that genes involved in calcium and TGF-beta signalling pathways were significantly more expressed in the non-secreting than in the secreting season. These changes in gene expression correlated with alterations in scented gland size. Both calcium and TGF-beta signalling pathways are important regulators of cell apoptosis, which may thus be involved in muskrat scented gland degeneration.
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Registered trials
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