ArticlePloS one2017
Persistent low serum zinc is associated with recurrent sepsis in critically ill patients - A pilot study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Prognostic Value of Serum Zinc Levels in Acutely Hospitalized Patients: a Systematic Review.Biological trace element research · 2021Pooled it
- Observational
- Zinc regulates the balance of specific gut microbiota through MTF1/Nrf2 and mitigates ferroptosis through activation of PINK1/Parkin/mitophagy via the gut-kidney axis in sepsis-associated acute kidney injury in pregnant mice.Apoptosis : an international journal on programmed cell death · 2026Article
- Low zinc status and long-term risk of incident sepsis in patients with type 2 diabetes: a multicenter cohort study.Frontiers in nutrition · 2026Article
- Association between zinc deficiency and adverse outcomes in patients with dementia: a matched cohort study.Frontiers in nutrition · 2026Article
- Is the Concentration of Trace Elements Zinc, Selenium, Copper, Manganese, and Iron a Predictor of Clinical Outcomes in Critically Ill Trauma Patients?Biological trace element research · 2025Article
- Article
- Circulating micronutrient levels and their association with sepsis susceptibility and severity: a Mendelian randomization study.Frontiers in genetics · 2024Article
- The Anti-Oxidative, Anti-Inflammatory, Anti-Apoptotic, and Anti-Necroptotic Role of Zinc in COVID-19 and Sepsis.Antioxidants (Basel, Switzerland) · 2023Review
- The Role of Diet and Supplements in the Prevention and Progression of COVID-19: Current Knowledge and Open Issues.Preventive nutrition and food science · 2022Review
- Free Zinc as a Predictive Marker for COVID-19 Mortality Risk.Nutrients · 2022Article
- Zinc and gut microbiota in health and gastrointestinal disease under the COVID-19 suggestion.BioFactors (Oxford, England) · 2022Review
- "MATH+" Multi-Modal Hospital Treatment Protocol for COVID-19 Infection: Clinical and Scientific Rationale.Journal of clinical medicine research · 2022Review
- Zinc deficiency as a possible risk factor for increased susceptibility and severe progression of Corona Virus Disease 19.The British journal of nutrition · 2022Review
- Ginkgolic acid promotes inflammation and macrophage apoptosisFrontiers in medicine · 2022Article
- Retrospective observational study evaluating zinc plasma level in patients undergoing thoracoabdominal aortic aneurysm repair and its correlation with outcome.Scientific reports · 2021Observational
- The correlation between serum selenium, zinc, and COVID-19 severity: an observational study.BMC infectious diseases · 2021Observational
- Statins in COVID-19 Therapy.Life (Basel, Switzerland) · 2021Review
- How Have Nutrition Practices in the ICU Changed in the Last Decade (2011-2020): A Scoping Review.Cureus · 2021Article
- Micronutrients in Sepsis and COVID-19: A Narrative Review on What We Have Learned and What We Want to Know in Future Trials.Medicina (Kaunas, Lithuania) · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc is an essential trace element for both pathogens and hosts. Hypozincemia is a well known phenomenon in sepsis patients and represents the innate immune systems attempt to deprive pathogens of zinc. However little is known about course, restitution and prognostic value of serum zinc levels in sepsis patients. We performed a prospective observational single-center study set in a tertiary care university hospital intensive care unit. Serum zinc levels were singularly measured of healthy controls and sequentially of surgical sepsis patients and surgical patients over a 8-day period. Throughout the study period, we report significantly decreased serum zinc levels in surgical and surgical sepsis patients compared to healthy controls. Lower serum zinc levels in surgical sepsis patients were associated with a higher susceptibility to a recurrent sepsis episode. Furthermore, surgical sepsis patients with a higher number of organ dysfunctions and increased in-hospital mortality at day 28 and 90 showed lower serum zinc levels at admission. We report serum zinc levels as a promising biomarker in the diagnosis and evaluation of sepsis patients. However, it is still unclear whether these findings are caused by an over-amplified redistribution of zinc during acute-phase response, or whether the critically ill patients were zinc deficient before sepsis.
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