ArticlePLoS computational biology2017
Mechanisms underlying different onset patterns of focal seizures.
Article in PLoS computational biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 69 citations in OpenAlex.
- Antiseizure Networks.Epilepsy currents · 2026Article
- Seizure Sources Can Be Imaged from Scalp EEG by Means of Biophysically Constrained Deep Neural Networks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Seizure onset and offset pattern determine the entrainment of the cortex and substantia nigra in the nonhuman primate model of focal temporal lobe seizures.bioRxiv : the preprint server for biology · 2024Article
- Article
- Temporal stability of intracranial electroencephalographic abnormality maps for localizing epileptogenic tissue.Epilepsia · 2023Article
- Spatial organisation of the mesoscale connectome: A feature influencing synchrony and metastability of network dynamics.PLoS computational biology · 2023Article
- Fecal incontinence as the sole presentation of focal epilepsy; a case report.Oxford medical case reports · 2023Article
- Synchronization and oscillation behaviors of excitatory and inhibitory populations with spike-timing-dependent plasticity.Cognitive neurodynamics · 2023Article
- Evaluation of Pharmacology and Pathophysiology Knowledge of Epilepsy among Senior Pharmacy Students: A Single Center Experience.Medicina (Kaunas, Lithuania) · 2023Article
- The role of epidemic spreading in seizure dynamics and epilepsy surgery.Network neuroscience (Cambridge, Mass.) · 2023Article
- Weak self-supervised learning for seizure forecasting: a feasibility study.Royal Society open science · 2022Article
- In vitro ictogenesis is stochastic at the single neuron level.Brain : a journal of neurology · 2022Article
- A unified physiological framework of transitions between seizures, sustained ictal activity and depolarization block at the single neuron level.Journal of computational neuroscience · 2022Article
- Dynamical Network Models From EEG and MEG for Epilepsy Surgery-A Quantitative Approach.Frontiers in neurology · 2022Review
- Multiple mechanisms shape the relationship between pathway and duration of focal seizures.Brain communications · 2022Article
- Wheels Within Wheels: Theory and Practice of Epileptic Networks.Epilepsy currents · 2021Article
- Evidence for spreading seizure as a cause of theta-alpha activity electrographic pattern in stereo-EEG seizure recordings.PLoS computational biology · 2021Article
- Data-driven method to infer the seizure propagation patterns in an epileptic brain from intracranial electroencephalography.PLoS computational biology · 2021Article
- Combination of Matching Responsive Stimulations of Hippocampus and Subiculum for Effective Seizure Suppression in Temporal Lobe Epilepsy.Frontiers in neurology · 2021Article
- Active probing to highlight approaching transitions to ictal states in coupled neural mass models.PLoS computational biology · 2021Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Focal seizures are episodes of pathological brain activity that appear to arise from a localised area of the brain. The onset patterns of focal seizure activity have been studied intensively, and they have largely been distinguished into two types-low amplitude fast oscillations (LAF), or high amplitude spikes (HAS). Here we explore whether these two patterns arise from fundamentally different mechanisms. Here, we use a previously established computational model of neocortical tissue, and validate it as an adequate model using clinical recordings of focal seizures. We then reproduce the two onset patterns in their most defining properties and investigate the possible mechanisms underlying the different focal seizure onset patterns in the model. We show that the two patterns are associated with different mechanisms at the spatial scale of a single ECoG electrode. The LAF onset is initiated by independent patches of localised activity, which slowly invade the surrounding tissue and coalesce over time. In contrast, the HAS onset is a global, systemic transition to a coexisting seizure state triggered by a local event. We find that such a global transition is enabled by an increase in the excitability of the "healthy" surrounding tissue, which by itself does not generate seizures, but can support seizure activity when incited. In our simulations, the difference in surrounding tissue excitability also offers a simple explanation of the clinically reported difference in surgical outcomes. Finally, we demonstrate in the model how changes in tissue excitability could be elucidated, in principle, using active stimulation. Taken together, our modelling results suggest that the excitability of the tissue surrounding the seizure core may play a determining role in the seizure onset pattern, as well as in the surgical outcome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.