Evidence map›Paper›PMID 28471837›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2017

Changing Dynamics of HIV Transmission in Côte d'Ivoire: Modeling Who Acquired and Transmitted Infections and Estimating the Impact of Past HIV Interventions (1976-2015).

Mathieu Maheu-Giroux, Juan F Vesga, Souleymane Diabaté, Michel Alary, Stefan Baral, Daouda Diouf, Kouamé Abo, Marie-Claude Boily

Open access · greenAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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  12. HIV prevention in Africa: is VMMC useful and acceptable?International journal of impotence research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 5 countries.

Mathieu Maheu-Giroux*Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montréal, Canada; †Department of Infectious Disease Epidemiology, Imperial College London, St Mary's Hospital, London, United Kingdom; ‡Centre de recherche du CHU de Québec-Université Laval, Québec, Canada; §Département d'infectiologie et santé publique, Université Alassane Ouattara, Bouaké, Côte d'Ivoire; ‖Département de médecine sociale et préventive, Université Laval, Québec, Canada; ¶Key Populations Program, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; #Enda Santé, Dakar, Sénégal; and **Programme National de Lutte Contre le SIDA, Ministère de la santé et de l'hygiène publique, Abidjan, Côte d'Ivoire.
Juan F Vesga
Souleymane Diabaté
Michel Alary
Stefan Baral
Daouda Diouf
Kouamé Abo
Marie-Claude Boily
Environment and Development Action Third World · SNImperial College London · GBJohns Hopkins University · USMcGill University · CASt Mary's Hospital · GBUniversité Alassane Ouattara · CIUniversité Laval · CA

Funding

SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
CIHRNIAID NIH HHS UM1 AI068617
6 · The paper itself

Abstract

introductionUnderstanding the impact of past interventions and how it affected transmission dynamics is key to guiding prevention efforts. We estimated the population-level impact of condom, antiretroviral therapy (ART), and prevention of mother-to-child transmission activities on HIV transmission and the contribution of key risk factors on HIV acquisition and transmission.

methodsAn age-stratified dynamical model of sexual and vertical HIV transmission among the general population, female sex workers (FSW), and men who have sex with men was calibrated to detailed prevalence and intervention data. We estimated the fraction of HIV infections averted by the interventions, and the fraction of incident infections acquired and transmitted by different populations over successive 10-year periods (1976-2015).

resultsOverall, condom use averted 61% (95% credible intervals: 56%-66%) of all adult infections during 1987-2015 mainly because of increased use by FSW (46% of infections averted). In comparison, ART prevented 15% (10%-19%) of adult infections during 2010-2015. As a result, FSW initially (1976-1985) contributed 95% (91%-97%) of all new infections, declining to 19% (11%-27%) during 2005-2015. Older men and clients mixing with non-FSW are currently the highest contributors to transmission. Men who have sex with men contributed ≤4% transmissions throughout. Young women (15-24 years; excluding FSW) do not transmit more infections than they acquired.

conclusionsEarly increases in condom use, mainly by FSW, have substantially reduced HIV transmission. Clients of FSWs and older men have become the main source of transmission, whereas young women remain at increased risk. Strengthening prevention and scaling-up of ART, particularly to FSW and clients of female sex workers, is important.

Indexed as

Sentinel SurveillanceAdolescentAdultAnti-HIV AgentsCondomsCote d'IvoireDisease Transmission, InfectiousFemaleHealth EducationHealth Knowledge, Attitudes, PracticeHealth PromotionHIV InfectionsHumansMaleMiddle AgedModels, TheoreticalAnti-HIV Agents

Identifiers

PMID28471837
PMCPMC5508974
OpenAlexW2611337603

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.