Evidence map›Paper›PMID 28471543›Full record

ArticleJournal of magnetic resonance imaging : JMRI2018

MRI and biomechanics multidimensional data analysis reveals R

Valentina Pedoia, Jenny Haefeli, Kazuhito Morioka, Hsiang-Ling Teng, Lorenzo Nardo, Richard B Souza, Adam R Ferguson, Sharmila Majumdar

Open access · greenAbstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Effects of TJournal of magnetic resonance imaging : JMRI · 2024
    Article
  6. Synthetic Knee MRI TBioengineering (Basel, Switzerland) · 2023
    Article
  7. Review
  8. Review
  9. Article
  10. Topological data analysis in biomedicine: A review.Journal of biomedical informatics · 2022
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Machine learning in knee osteoarthritis: A review.Osteoarthritis and cartilage open · 2020
    Review
  20. Diagnosing osteoarthritis from TOsteoarthritis and cartilage · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Valentina PedoiaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Jenny HaefeliWeill Institute for Neurosciences, Department of Neurological Surgery, Brain and Spinal Injury Center, University of California, San Francisco, California, USA.
Kazuhito MoriokaWeill Institute for Neurosciences, Department of Neurological Surgery, Brain and Spinal Injury Center, University of California, San Francisco, California, USA.
Hsiang-Ling TengDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Lorenzo NardoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Richard B SouzaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Adam R FergusonWeill Institute for Neurosciences, Department of Neurological Surgery, Brain and Spinal Injury Center, University of California, San Francisco, California, USA.
Sharmila MajumdarDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
University of California System · USNeurological Surgery · USUniversity of California, San Francisco · USZero to Three · US

Funding

MRI TO STUDY CARTILAGE/BONE INTERACTIONSR01AR046905 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 1999 to 2015
$6.3M
Translation of Quantitative Imaging in OsteoarthritisP50AR060752 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOUZA, RICHARD BRIAN · 2011 to 2015
$6.2M
UCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2014 to 2018
$3.0M
Maladaptive Plasticity in Spinal Cord Injury: Cellular MechanismsR01NS088475 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERGUSON, ADAM R · 2015 to 2019
$1.7M
Bioinformatics For Translational Spinal Cord Injury ResearchR01NS067092 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERGUSON, ADAM R · 2010 to 2014
$1.6M
Contact mechanics, neuromuscular control, and cartilage composition in knee OAR01AR062370 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOUZA, RICHARD BRIAN · 2011 to 2014
$1.1M
A Multi-Disciplinary Multi-Development Core on Musculoskeletal ImagingP30AR058899 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2009 to 2010
$955k
Multidimensional MRI-based Big Data Analytics to Study OsteoarthritisK99AR070902 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PEDOIA, VALENTINA · 2017 to 2017
$94k
NIAMS NIH HHS K99 AR070902NIAMS NIH HHS P30 AR058899NIAMS NIH HHS P30 AR066262NIAMS NIH HHS P50 AR060752NIAMS NIH HHS R01 AR046905NIAMS NIH HHS R01 AR062370NINDS NIH HHS R01 NS067092NINDS NIH HHS R01 NS088475
6 · The paper itself

Abstract

purposeTo couple quantitative compositional MRI, gait analysis, and machine learning multidimensional data analysis to study osteoarthritis (OA). OA is a multifactorial disorder accompanied by biochemical and morphological changes in the articular cartilage, modulated by skeletal biomechanics and gait. While we can now acquire detailed information about the knee joint structure and function, we are not yet able to leverage the multifactorial factors for diagnosis and disease management of knee OA. MATERIALS AND

methodsWe mapped 178 subjects in a multidimensional space integrating: demographic, clinical information, gait kinematics and kinetics, cartilage compositional T

resultsThe results of the TDA showed a network composed of three main patient subpopulations, thus potentially identifying new phenotypes. T

conclusionThe analysis presented demonstrates some of the complex multitissue biochemical and biomechanical interactions that define joint degeneration and OA using a multidimensional approach, and potentially indicates that R LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:78-90.

Indexed as

Image Processing, Computer-AssistedMagnetic Resonance ImagingAdultAgedBiomechanical PhenomenaBody Mass IndexCartilageCase-Control StudiesDisease ProgressionFalse Positive ReactionsFemaleFemurGaitHumansLongitudinal StudiesMachine Learningmachine learningMRIosteoarthritisprecision medicineR2-R1ρT1ρ/T2topological data analysis

Identifiers

PMID28471543
PMCPMC5967390
OpenAlexW2611499204

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.