Evidence map›Paper›PMID 28471517›Full record

ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2017

The Duffy antigen receptor for chemokines regulates asthma pathophysiology.

D G Chapman, E B Mougey, J L Van der Velden, K G Lahue, M Aliyeva, N Daphtary, K L George, S M Hoffman, R W Schneider, R P Tracy and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. House Dust Mite Allergy Under Changing Environments.Allergy, asthma & immunology research · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

D G ChapmanDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT, USA.ORCID http://orcid.org/0000-0002-8211-1817
E B MougeyNemours Pharmacogenetics Center, Nemours Children's Clinic, Jacksonville, FL, USA.
J L Van der VeldenDepartment of Pathology, University of Vermont College of Medicine, Burlington, VT, USA.
K G LahueDepartment of Pathology, University of Vermont College of Medicine, Burlington, VT, USA.
M AliyevaDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
N DaphtaryDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
K L GeorgeNemours Pharmacogenetics Center, Nemours Children's Clinic, Jacksonville, FL, USA.
S M HoffmanDepartment of Pathology, University of Vermont College of Medicine, Burlington, VT, USA.
R W SchneiderDepartment of Pathology, University of Vermont College of Medicine, Burlington, VT, USA.
R P TracyDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
G S WorthenChildren's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
M E PoynterDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
S P PetersSection on Pulmonary, Critical Care, Allergy & Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, NC, USA.
J J LimaNemours Pharmacogenetics Center, Nemours Children's Clinic, Jacksonville, FL, USA.
Y M W Janssen-HeiningerDepartment of Pathology, University of Vermont College of Medicine, Burlington, VT, USA.
C G IrvinDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
University of Vermont · USNemours Children’s Clinic · USChildren's Hospital of Philadelphia · USWake Forest University · US

Funding

Vermont Immunology/Infectious Diseases CenterP30GM118228 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2016 to 2021
$6.8M
S-glutathionylation chemistry in fibrotic lung remodelingR35HL135828 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JANSSEN-HEININGER, YVONNE M. W. · 2017 to 2023
$6.5M
Obese Allergic Asthma and the Impact of Weight Loss on Airway Epithelial FunctionR01HL133920 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI DIXON, ANNE E, POYNTER, MATTHEW E · 2016 to 2020
$3.9M
Translational Research in Lung Biology and DiseaseP30GM103532 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI IRVIN, CHARLES G · 2012 to 2016
$3.7M
Epithelial JNK-TGFb1 Signaling Axis in Airway RemodelingR01HL085464 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JANSSEN-HEININGER, YVONNE M. W. · 2008 to 2016
$3.0M
NHLBI NIH HHS R01 HL085464NHLBI NIH HHS R01 HL133920NHLBI NIH HHS R35 HL135828NIGMS NIH HHS P30 GM103532NIGMS NIH HHS P30 GM118228
6 · The paper itself

Abstract

backgroundThe Duffy antigen receptor for chemokines (DARC) is an atypical receptor that regulates pro-inflammatory cytokines. However, the role of DARC in asthma pathophysiology is unknown.

objectiveTo determine the role of DARC in allergic airways disease in mice, and the association between DARC single nucleotide polymorphisms (SNPs) and clinical outcomes in patients with asthma.

methodsMice with targeted disruption of the Darc gene (Darc

resultsTotal airway inflammation following HDM did not differ between Darc CONCLUSIONS AND CLINICAL RELEVANCE: Our animal model and human patient data suggest a novel role for DARC in the temporal regulation in asthma pathophysiology and symptoms.

Indexed as

AsthmaChemokinesDuffy Blood-Group SystemReceptors, Cell SurfaceAnimalsAntigens, DermatophagoidesDisease Models, AnimalDisease SusceptibilityFemaleGene ExpressionGenetic LociHumansLeukocytesMaleMiceMice, KnockoutACKR1 protein, humanAckr1 protein mouseAntigens, DermatophagoidesChemokinesDuffy Blood-Group SystemReceptors, Cell Surfaceairway hyperresponsivenessasthmaDuffy antigen receptor for chemokines

Identifiers

PMID28471517
PMCPMC5578916
OpenAlexW2611650233

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.