ArticleProceedings of the National Academy of Sciences of the United States of America1988
Disruption of Dictyostelium discoideum morphogenesis by overproduction of cAMP phosphodiesterase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Diverse Roles of the Multiple Phosphodiesterases in the Regulation of Cyclic Nucleotide Signaling inCells · 2025Review
- A telomerase with novel non-canonical roles: TERT controls cellular aggregation and tissue size in Dictyostelium.PLoS genetics · 2019Article
- Nse1 and Nse4, subunits of the Smc5-Smc6 complex, are involved in Dictyostelium development upon starvation.Development, growth & differentiation · 2015Article
- A cell number counting factor alters cell metabolism.Communicative & integrative biology · 2009Article
- The group migration of Dictyostelium cells is regulated by extracellular chemoattractant degradation.Molecular biology of the cell · 2009Article
- A protein with similarity to PTEN regulates aggregation territory size by decreasing cyclic AMP pulse size during Dictyostelium discoideum development.Eukaryotic cell · 2008Article
- Combining experiments and modelling to understand size regulation in Dictyostelium discoideum.Journal of the Royal Society, Interface · 2008Review
- CnrN regulates Dictyostelium group size using a counting factor-independent mechanism.Communicative & integrative biology · 2008Article
- A cell-counting factor regulating structure size in Dictyostelium.Genes & development · 1999Article
- Origin and evolution of circular waves and spirals in Dictyostelium discoideum territories.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Dual role of cAMP during Dictyostelium development.Experientia · 1995Review
- Specific expression of a gene encoding a novel calcium-binding protein, CAF-1, during transition of Dictyostelium cells from growth to differentiation.Development, growth & differentiation · 1995Article
- Chemotactic sorting to cAMP in the multicellular stages of Dictyostelium development.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Regulation of slug size by the cell adhesion molecule gp80 in Dictyostelium discoideum.Cell regulation · 1990Article
- Conditions that alter intracellular cAMP levels affect expression of the cAMP phosphodiesterase gene in Dictyostelium.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- The cyclic nucleotide phosphodiesterase gene of Dictyostelium discoideum contains three promoters specific for growth, aggregation, and late development.Molecular and cellular biology · 1990Article
- The cyclic nucleotide phosphodiesterase gene of Dictyostelium discoideum utilizes alternate promoters and splicing for the synthesis of multiple mRNAs.Molecular and cellular biology · 1989Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The development and cellular differentiation of Dictyostelium discoideum are disrupted in transformants secreting high levels of the cyclic nucleotide phosphodiesterase. The aggregation of these cells in the early stage of development proceeds rapidly and without the formation of organized streams. The later stages of development, in which differentiation into stalk and spore cells normally takes place, are completely blocked so that the transformants remain in spherical clusters of undifferentiated cells that do not elaborate the tip structure that regulates morphogenesis. These effects are due to overproduction of extracellular phosphodiesterase and demonstrate the role of cAMP during the aggregation phase of development as well as in the control of differentiation and pattern formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.