Evidence map›Paper›PMID 28471447›Full record

ArticleCell death & disease2017

MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer.

Chen Liang, Xing Zhang, Hui-Min Wang, Xiao-Min Liu, Xin-Ju Zhang, Bo Zheng, Guang-Ren Qian, Zhong-Liang Ma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 154 citations in OpenAlex.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chen LiangLab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, China.
Xing ZhangSchool of Environmental Science and Engineering, Shanghai University, Shanghai, 200444, China.
Hui-Min WangLab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, China.
Xiao-Min LiuLab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, China.
Xin-Ju ZhangLab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, China.
Bo ZhengLab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, China.
Guang-Ren QianSchool of Environmental Science and Engineering, Shanghai University, Shanghai, 200444, China.
Zhong-Liang MaLab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, China.
Shanghai University · CNShanghai University of Engineering Science · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer is the major form of cancer resulting in cancer-related mortality around the world. MicroRNAs are endogenous small non-coding single-stranded RNAs, which can engage in the regulation of gene expression. In this study, miR-18a-5p significantly upregulated in non-small cell lung cancer (NSCLC) tissues and NSCLC cell lines, suggesting an oncogenic function in lung cancer. Additionally, miR-18a-5p can promote carcinogenesis by directly targeting interferon regulatory factor 2 (IRF2). Further experiments indicated that IRF2 can increase cell apoptosis, inhibit cell proliferation and migration ability. Our study demonstrates that miR-18a-5p promotes autophagy in NSCLC. Collectively, these results indicate that miR-18a-5p can not only promote NSCLC by suppressing IRF2, but also will be a promising target in the near future.

Indexed as

A549 CellsAnimalsAntagomirsAutophagyBase SequenceCadherinsCarcinoma, Non-Small-Cell LungCell Line, TumorCell MovementCell ProliferationErbB ReceptorsHEK293 CellsHumansInterferon Regulatory Factor-2Ki-67 AntigenLung NeoplasmsAntagomirsCadherinsEGFR protein, mouseErbB ReceptorsInterferon Regulatory Factor-2IRF2 protein, humanKi-67 AntigenMicroRNAsMIRN18A microRNA, human

Identifiers

PMID28471447
PMCPMC5520692
OpenAlexW2611499037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.