Evidence map›Paper›PMID 28471300›Full record

ReviewSmall GTPases2018

Rab GTPases and cell division.

Paulius Gibieža, Rytis Prekeris

Open access · bronzeAbstract readReview
In one paragraph

Review in Small GTPases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  6. Unravelling the Transcriptional Response ofInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Paulius Gibiežaa Institute of Cardiology, Lithuanian University of Health Sciences , Kaunas , Lithuania.ORCID 0000-0003-0432-9690
Rytis Prekerisb Department of Cell and Developmental Biology , University of Colorado Anschutz Medical Campus , Aurora , CO , USA.
Lithuanian University of Health Sciences · LTUniversity of Colorado Anschutz Medical Campus · US

Funding

Molecular Mechanisms Regulating Epithelial Cell Apical Polarity and CiliogenesisR01DK064380 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Rytis Prekeris · 2004 to 2026
$7.1M
NIDDK NIH HHS R01 DK064380
6 · The paper itself

Abstract

Cytokinesis is a complex cellular process that leads to a physical separation of two daughter cells. The key to a successful cytokinesis is a coordinated reorganization of cellular cytoskeleton and membrane trafficking pathways. Consequently, Rab GTPases recently emerged as major regulators of cellular division. Rabs belong to a superfamily of small monomeric GTPases that regulate a diverse array of cellular functions. Rabs in particular are well-established regulators of membrane transport and have been shown to mediate several membrane transport steps including vesicle formation, molecular motor-dependent vesicle transport and targeting of transport vesicles and organelles to their correct destinations. Significantly, several Rab GTPases also have been shown to function in regulating cell division. In this review, we discuss latest findings about the function of Rabs and polarized membrane transport during different steps of cytokinesis as well as during the final stage of cell division known as abscission.

Indexed as

Cell DivisionAnimalsCell PolarityCytokinesisHepatocytesHumansrab GTP-Binding Proteinsrab GTP-Binding Proteinsabscissioncell polaritycytokinesisendosomesRab GTPases

Identifiers

PMID28471300
PMCPMC5902206
OpenAlexW2611539142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.